Featured Research

from universities, journals, and other organizations

New Insights Into Vaccination For HIV

Date:
January 31, 2008
Source:
Public Library of Science
Summary:
Scientists have developed new tools and paradigms to understand immune evasion from HIV. They show that both prior vaccination and timing influence the rates of immune escape, providing further insight into the effectiveness of T cell immunity to HIV.

A group of Australian researchers at the Universities of Melbourne and New South Wales have developed new tools and paradigms to understand immune evasion from HIV. The study shows that both prior vaccination and timing influence the rates of immune escape, providing further insight into the effectiveness of T cell immunity to HIV.

Related Articles


An HIV vaccine is urgently needed. A major hurdle is the rapid evolution of HIV and its ability to mutate to escape effective immunity. Low levels of mutant virus cannot be detected with standard techniques, making it difficult to study the evolution of mutant viruses.

The group, led by PhD student Liyen Loh and Dr. Stephen Kent, developed highly sensitive assays to track mutant viruses. They show that vaccination of macaques against SIV (a simian AIDS virus) results in the rapid selection of mutant viruses. In contrast, escape mutants evolve much more slowly when they appear later during infection.

Mutant viruses, however, result in some "fitness" cost and they revert back when transmitted to a new host. Reversion of mutant viruses also follows the same principles -- rapid during acute infection and slower during chronic infection. These insights suggest new ways to improve HIV vaccines.

Journal citation: Loh L, Petravic J, Batten CJ, Davenport MP, Kent SJ (2008) Vaccination and timing influence SIV immune escape viral dynamics in vivo. PLoS Pathog 4(1): e12. doi:10.1371/journal.ppat.0040012http://pathogens.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.ppat.0040012


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "New Insights Into Vaccination For HIV." ScienceDaily. ScienceDaily, 31 January 2008. <www.sciencedaily.com/releases/2008/01/080124233642.htm>.
Public Library of Science. (2008, January 31). New Insights Into Vaccination For HIV. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2008/01/080124233642.htm
Public Library of Science. "New Insights Into Vaccination For HIV." ScienceDaily. www.sciencedaily.com/releases/2008/01/080124233642.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins