Featured Research

from universities, journals, and other organizations

New Insights Into Vaccination For HIV

Date:
January 31, 2008
Source:
Public Library of Science
Summary:
Scientists have developed new tools and paradigms to understand immune evasion from HIV. They show that both prior vaccination and timing influence the rates of immune escape, providing further insight into the effectiveness of T cell immunity to HIV.

A group of Australian researchers at the Universities of Melbourne and New South Wales have developed new tools and paradigms to understand immune evasion from HIV. The study shows that both prior vaccination and timing influence the rates of immune escape, providing further insight into the effectiveness of T cell immunity to HIV.

An HIV vaccine is urgently needed. A major hurdle is the rapid evolution of HIV and its ability to mutate to escape effective immunity. Low levels of mutant virus cannot be detected with standard techniques, making it difficult to study the evolution of mutant viruses.

The group, led by PhD student Liyen Loh and Dr. Stephen Kent, developed highly sensitive assays to track mutant viruses. They show that vaccination of macaques against SIV (a simian AIDS virus) results in the rapid selection of mutant viruses. In contrast, escape mutants evolve much more slowly when they appear later during infection.

Mutant viruses, however, result in some "fitness" cost and they revert back when transmitted to a new host. Reversion of mutant viruses also follows the same principles -- rapid during acute infection and slower during chronic infection. These insights suggest new ways to improve HIV vaccines.

Journal citation: Loh L, Petravic J, Batten CJ, Davenport MP, Kent SJ (2008) Vaccination and timing influence SIV immune escape viral dynamics in vivo. PLoS Pathog 4(1): e12. doi:10.1371/journal.ppat.0040012http://pathogens.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.ppat.0040012


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "New Insights Into Vaccination For HIV." ScienceDaily. ScienceDaily, 31 January 2008. <www.sciencedaily.com/releases/2008/01/080124233642.htm>.
Public Library of Science. (2008, January 31). New Insights Into Vaccination For HIV. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2008/01/080124233642.htm
Public Library of Science. "New Insights Into Vaccination For HIV." ScienceDaily. www.sciencedaily.com/releases/2008/01/080124233642.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins