Featured Research

from universities, journals, and other organizations

Gene Predicts Heart Attack Response And Cardiac Damage

Date:
February 4, 2008
Source:
Yale University
Summary:
A protein influences the response of the heart to a lack of oxygen and blood flow, such as occurs during a heart attack. This finding may present a new therapeutic approach to treating loss of blood flow and oxygen to the heart.

A protein has been found that influences the response of the heart to a lack of oxygen and blood flow, such as occurs during a heart attack, a team of Yale School of Medicine researchers report in the journal Nature.

This finding may present a new therapeutic approach to treating loss of blood flow and oxygen to the heart.

The protein, macrophage migration inhibitory factor (MIF), was found to activate an important cellular stress response enzyme called AMP-activated protein kinase (AMPK). AMPK is a key regulator of cellular energy balance and protects the heart from injury during a heart attack.

MIF had previously been shown to regulate the immune response, contributing to disease processes such as hardening of the arteries, arthritis, and the body's response to infection.

"We found that when MIF is released in response to a lack of oxygen, it causes the activation of AMPK," said Richard Bucala, M.D., a professor of rheumatology and pathology who co-authored the study. "Thus, this protein which contributes to inflammatory diseases has a protective metabolic effect in the heart."

The researchers discovered that mice lacking the MIF gene had a deficient AMPK response and suffered more severe heart attacks than mice with an intact MIF gene. A common variation in the MIF gene in people also leads to lower levels of MIF protein expression. The team's research showed that cells from people with this genetic variant also have less activation of AMPK, which might place them at higher risk for cardiac damage during a heart attack.

"This suggests that we might be able to identify individuals, based on their genetic characteristics, who are likely to suffer more cardiac damage during a heart attack," said senior author Lawrence Young, M.D., professor of cardiovascular medicine, and physiology.

Co-authors include Edward Miller, Ji Li, Lin Leng, Courtney McDonald, and Toshiya Atsumi.

Journal reference: Nature online: doi:10.1038/nature06504


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Gene Predicts Heart Attack Response And Cardiac Damage." ScienceDaily. ScienceDaily, 4 February 2008. <www.sciencedaily.com/releases/2008/01/080130141616.htm>.
Yale University. (2008, February 4). Gene Predicts Heart Attack Response And Cardiac Damage. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/01/080130141616.htm
Yale University. "Gene Predicts Heart Attack Response And Cardiac Damage." ScienceDaily. www.sciencedaily.com/releases/2008/01/080130141616.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins