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The Way A Protein Is Folded Affects The Molecular Dance Of Water

Date:
February 11, 2008
Source:
Ruhr-Universität-Bochum
Summary:
Scientists have shown, with terahertz (THz) spectroscopy, that proteins do significantly modify water molecules in their environment: The water molecules, which generally move around like disco dancers in their collective network motions behave more like in a neat minuet under protein influence. Protein folding also changes the dancing steps of water.

While the folded protein affects up to 1,000 water molecules in its environment, the partly unfolded protein has a lesser affect on water.
Credit: Image courtesy of Ruhr-Universität-Bochum

Scientists from Bochum, Illinois, and Nevada were able to prove with terahertz (THz) spectroscopy that proteins do modify water molecules in their environment to a long range extent: The water molecules, which generally move around like disco dancers in their collective network motions behave more like in a neat minuet under protein influence.

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The group by Prof. Dr. Martina Havenith-Newen (Physical Chemistry II Dpt., RUB) managed to find out more about the rules of this dance. They could show that protein folding changes the dancing steps of water. A partly unfolded protein will affect water molecules within the dynamical hydration shell to a much less extent than a folded one does. The higher the flexibility of the protein, the less affected is the water.

In water, weak bonds between two adjacent water molecules, referred to as the hydrogen bridge bonds, are continuously opening and closing: this happens on average every 1.3 pico seconds (one pico second = 10 power -12 seconds). “Even small concentrations of proteins in water lead to measurable changes in collective movements“, Prof. Havenith-Newen explains the results of previous studies with THz spectroscopy.

Folding is the Important Thing

While the folded protein affects up to 1,000 water molecules in its environment, this is only true for the partly unfolded protein to a small extent. If one modifies some parts of the protein through mutation, the effect is less remarkable. These observations were now made by the scientific teams of Prof. Havenith-Newen, Prof. Dr. Martin Gruebele, and Prof. Dr. David M. Leitner from RUB, the University of Illinois and the University of Nevada, respectively.

“This shows that water in the environment of folded proteins is different from that in the environment of an unfolded protein“, Prof. Havenith-Newen concludes. ”This will further support the hypothesis that protein and water are not independent of each other and do influence each other – an effect which has been considered decisive for protein folding, and which may be highly important for protein functions.“

New, Highly Precise Method of Proof

THz spectroscopy is a new, especially sensitive method of observing fast water network movement in the close vicinity of proteins with the THz frequencies ranging between microwave and infrared frequencies. Particularly strong THz laser radiation sources lasers, which has been used in chemistry for the first time by RUB, facilitates the observation of proteins in their natural environment during their fast dance with water molecules.

Journal reference: S. Ebbinghaus, S. J. Kim, M. Heyden, X. Yu, M. Gruebele, D.M. Leitner, and M. Havenith: Protein sequence- and pH-dependent hydration probed by Terahertz spectroscopy. In: Journal of the American Chemical Society, ASAP Article 10.1021/ja0746520 S0002-7863(07)04652-5, Web Release Date: February 5, 2008, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/asap/abs/ja0746520.html

Funding was provided by the Human Frontier Science Programme.


Story Source:

The above story is based on materials provided by Ruhr-Universität-Bochum. Note: Materials may be edited for content and length.


Cite This Page:

Ruhr-Universität-Bochum. "The Way A Protein Is Folded Affects The Molecular Dance Of Water." ScienceDaily. ScienceDaily, 11 February 2008. <www.sciencedaily.com/releases/2008/02/080206150538.htm>.
Ruhr-Universität-Bochum. (2008, February 11). The Way A Protein Is Folded Affects The Molecular Dance Of Water. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/02/080206150538.htm
Ruhr-Universität-Bochum. "The Way A Protein Is Folded Affects The Molecular Dance Of Water." ScienceDaily. www.sciencedaily.com/releases/2008/02/080206150538.htm (accessed October 30, 2014).

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