Featured Research

from universities, journals, and other organizations

Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice

Date:
February 10, 2008
Source:
Centre for Synthesis and Chemical Biology
Summary:
Significant pre-clinical results on the anti-tumor activity of Titanocene Y on human breast tumors and in a mouse model have just been published. In the mouse model, a decrease not only in tumor growth but also a reduction in tumor volume to around one-third was observed for the first time. In the human breast cancer, Titanocene Y showed cell death induction comparable to the widely-used chemotherapy drug Cisplatin.

Dr Matthias Tacke and his research team at the Centre for Synthesis and Chemical Biology and the School of Chemistry and Chemical Biology at University College Dublin have recently published highly significant preclinical results on the anti-tumour activity of Titanocene Y on human breast tumours and in a mouse model.

In the mouse model, a decrease not only in tumour growth but also a reduction in tumour volume to around one-third was observed for the first time. In the human breast cancer, Titanocene Y showed cell death induction comparable to the widely-used chemotherapy drug Cisplatin.

Dr Tacke's group has been working on anti-cancer drugs belonging to the titanocene family for five years. 25 novel compounds were initially synthesised in the lab, and were structurally identified and then biologically evaluated.

The most successful analogues so far, Titanocene X and Titanocene Y, have been shown in early in-vitro and ex-vitro experiments to target prostrate, cervix and renal cell cancers, as well as breast cancer cell lines. The researchers believe that titanocenes represent a novel series of promising antitumour agents.

According to Dr Tacke: "The successor molecule has been synthesised and has been shown to be 13 times more cytotoxic in vitro. Investigations of this candidate in the next mouse model are currently underway."

Journal reference: Beckhove, P., Oberschmidt, O., Hanauske, A. R., Pampillon, C., Schirrmacher, V., Sweeney, N. J., Strohfeldt, K., Tacke, M. Anti-Cancer Drugs 2007, 18: 311-315.


Story Source:

The above story is based on materials provided by Centre for Synthesis and Chemical Biology. Note: Materials may be edited for content and length.


Cite This Page:

Centre for Synthesis and Chemical Biology. "Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice." ScienceDaily. ScienceDaily, 10 February 2008. <www.sciencedaily.com/releases/2008/02/080206152424.htm>.
Centre for Synthesis and Chemical Biology. (2008, February 10). Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/02/080206152424.htm
Centre for Synthesis and Chemical Biology. "Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice." ScienceDaily. www.sciencedaily.com/releases/2008/02/080206152424.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins