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Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice

Date:
February 10, 2008
Source:
Centre for Synthesis and Chemical Biology
Summary:
Significant pre-clinical results on the anti-tumor activity of Titanocene Y on human breast tumors and in a mouse model have just been published. In the mouse model, a decrease not only in tumor growth but also a reduction in tumor volume to around one-third was observed for the first time. In the human breast cancer, Titanocene Y showed cell death induction comparable to the widely-used chemotherapy drug Cisplatin.
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Dr Matthias Tacke and his research team at the Centre for Synthesis and Chemical Biology and the School of Chemistry and Chemical Biology at University College Dublin have recently published highly significant preclinical results on the anti-tumour activity of Titanocene Y on human breast tumours and in a mouse model.

In the mouse model, a decrease not only in tumour growth but also a reduction in tumour volume to around one-third was observed for the first time. In the human breast cancer, Titanocene Y showed cell death induction comparable to the widely-used chemotherapy drug Cisplatin.

Dr Tacke's group has been working on anti-cancer drugs belonging to the titanocene family for five years. 25 novel compounds were initially synthesised in the lab, and were structurally identified and then biologically evaluated.

The most successful analogues so far, Titanocene X and Titanocene Y, have been shown in early in-vitro and ex-vitro experiments to target prostrate, cervix and renal cell cancers, as well as breast cancer cell lines. The researchers believe that titanocenes represent a novel series of promising antitumour agents.

According to Dr Tacke: "The successor molecule has been synthesised and has been shown to be 13 times more cytotoxic in vitro. Investigations of this candidate in the next mouse model are currently underway."

Journal reference: Beckhove, P., Oberschmidt, O., Hanauske, A. R., Pampillon, C., Schirrmacher, V., Sweeney, N. J., Strohfeldt, K., Tacke, M. Anti-Cancer Drugs 2007, 18: 311-315.


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The above post is reprinted from materials provided by Centre for Synthesis and Chemical Biology. Note: Materials may be edited for content and length.


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Centre for Synthesis and Chemical Biology. "Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice." ScienceDaily. ScienceDaily, 10 February 2008. <www.sciencedaily.com/releases/2008/02/080206152424.htm>.
Centre for Synthesis and Chemical Biology. (2008, February 10). Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice. ScienceDaily. Retrieved July 28, 2015 from www.sciencedaily.com/releases/2008/02/080206152424.htm
Centre for Synthesis and Chemical Biology. "Experimental Anti-cancer Drug Reduces Tumor Growth And Tumor Volume In Mice." ScienceDaily. www.sciencedaily.com/releases/2008/02/080206152424.htm (accessed July 28, 2015).

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