Featured Research

from universities, journals, and other organizations

Setting Up A Roadblock For Atherosclerosis

Date:
February 13, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Treatment with the antibiotic myriocin can halt the growth of established arterial plaques in mice, researchers report.

Treatment with the antibiotic myriocin can halt the growth of established arterial plaques in mice, researchers report.

Related Articles


Myriocin kills bacteria by disrupting the formation sphingomyelin, a fatty molecule that is a key part of their cell membranes. Since sphingomyelin is also a major component of fatty plaques that can build up in blood vessels, myriocin could be a potential treatment option for atherosclerosis. In fact, some studies have shown that myriocin can suppress the development of atherosclerosis in mice fed a high-fat diet.

Taking this idea one step further, Brett Garner and colleagues aimed to determine whether myriocin could suppress or even reverse pre-existing atherosclerotic lesions. Adult transgenic mice were fed a high-fat diet for 30 days to stimulate plaque formation, at which point the mice were transferred to either a regular diet or a diet containing myriocin.

The researchers then measured lesion size and found that myriocin significantly inhibited the progress of established atherosclerosis, which coincided with decreases in the concentration of sphingomyelin, cholesterol, and triglycerides in the blood.

Although the researchers did not observe any shrinkage of lesions, myriocin still could offer therapeutic benefits to individuals with early-stage atherosclerosis.

This research was reported in the Journal Of Lipid Research, February 7, 2008.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Setting Up A Roadblock For Atherosclerosis." ScienceDaily. ScienceDaily, 13 February 2008. <www.sciencedaily.com/releases/2008/02/080207202308.htm>.
American Society for Biochemistry and Molecular Biology. (2008, February 13). Setting Up A Roadblock For Atherosclerosis. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2008/02/080207202308.htm
American Society for Biochemistry and Molecular Biology. "Setting Up A Roadblock For Atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2008/02/080207202308.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins