Featured Research

from universities, journals, and other organizations

New Bone Created In Minimally Invasive Procedure

Date:
February 19, 2008
Source:
Yale University
Summary:
A new technique that combines bone marrow removal and injection of a hormone helps promote rapid formation of new bone at targeted locations in the body. The procedure creates new bone tissue that appears structurally and biologically normal and that endows the targeted bone with improved biomechanical properties at a rate and extent that would not be achievable by anabolic therapy alone.

The bone bioreactor: replacement of bone marrow by bone.
Credit: Image courtesy of Yale University

A new technique that combines bone marrow removal and injection of a hormone helps promote rapid formation of new bone at targeted locations in the body, it was reported by Yale School of Medicine recently in Tissue Engineering.

Related Articles


"This could radically change the way patients are currently treated for weakened or fractured hips, vertebrae and acute traumatic long bone fractures," said senior author Agnθs Vignery, associate professor of orthopedics.

She said currently available treatment requires surgery and artificial materials and often results in imperfect outcomes. "The ideal approach would be to create new bone where it is needed and at a faster rate," Vignery said.

The study in mice was done in collaboration with Unigene Laboratories, Inc. It evaluated the effect of bone marrow removal from particular sites followed by daily injections of anabolic agents such as parathyroid hormone (PTH).

The procedure creates new bone tissue that appears structurally and biologically normal and that endows the targeted bone with improved biomechanical properties at a rate and extent that would not be achievable by anabolic therapy alone, Vignery said.

"We have shown that it is the synergistic effect of mechanical marrow ablation and PTH that allows for this new bone to fill the marrow cavity," she said.

She said additional studies are underway that extend the results of this work in other animals and that will determine whether the newly formed bone can be preserved over a long period of time.

Reference: Tissue Engineering February 2008. Co-authors include Qing Zhang, Estaban Cuartas, W. Mark Saltzman, Maya Kotas, Mandy Ma, Sonali Rajan, Cιcile Chalouni, and Jodi Carlson, of Yale, as well as Nozer Mehta, James Gilligan, and Hua-Zhu Ke.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "New Bone Created In Minimally Invasive Procedure." ScienceDaily. ScienceDaily, 19 February 2008. <www.sciencedaily.com/releases/2008/02/080214153529.htm>.
Yale University. (2008, February 19). New Bone Created In Minimally Invasive Procedure. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2008/02/080214153529.htm
Yale University. "New Bone Created In Minimally Invasive Procedure." ScienceDaily. www.sciencedaily.com/releases/2008/02/080214153529.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) — Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) — AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) — A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins