Featured Research

from universities, journals, and other organizations

Early Warning: PSA Testing Can Predict Advanced Prostate Cancer, Study Shows

Date:
February 15, 2008
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
A single prostate specific antigen test taken before the age of 50 can be used to predict advanced prostate cancer in men up to 25 years in advance of a diagnosis, according to a new study. Prostate cancer is the most common cancer in American men after lung cancer. This year, more than 230,000 new cases will be diagnosed, and according to the American Cancer Society, more than 27,000 men died from prostate cancer in 2006.

A single prostate specific antigen (PSA) test taken before the age of 50 can be used to predict advanced prostate cancer in men up to 25 years in advance of a diagnosis, according to a new study published by researchers at Memorial Sloan-Kettering Cancer Center in New York and Lund University in Sweden. The findings should help physicians be able to identify men who would benefit from intensive prostate cancer screenings over their lifetime.

Previously, the team's research has shown that a single PSA test at age 50 or younger could predict the presence of prostate cancer in men up to 25 years in advance of diagnosis. "This latest study is a unique, natural experiment to test whether we can predict advanced prostate cancer many years before it is diagnosed," said lead author Hans Lilja, MD, PhD, a clinical chemist with joint appointments in the Departments of Surgery and Medicine at MSKCC.

Prostate cancer is the most common cancer in American men after lung cancer. This year, more than 230,000 new cases will be diagnosed, and according to the American Cancer Society, more than 27,000 men died from prostate cancer in 2006.

The findings are based on the research team's analysis of blood samples collected between 1974 and 1986 as part of a large, population-based study of middle aged men called the Malmφ Preventative Medicine study. The study cohort, in Malmφ, Sweden, included 161 men who had been diagnosed with advanced prostate cancer by 1999 and men of a similar age who had not developed cancer by that time.

The results showed that the total PSA level was an accurate predictor of advanced cancer diagnosis in men later in life. The majority, 66 percent, of advanced cancers were seen in men whose PSA levels were in the top 20 percent (total PSA > 0.9 ng/ml). The average length of time from blood test to cancer diagnosis was 17 years.

While this data does not have any immediate implications for general prostate cancer screening guidelines, Dr. Lilja adds, "We have found that a single PSA test taken at or before age 50 is a very strong predictor of advanced prostate cancer diagnosed up to 25 years later. This suggests the possibility of using an early PSA test determine which men should be the focus of the most intensive screening efforts."

Vigilant, targeted screenings in high- risk men could allow physicians to intervene when the cancer is at an early stage.

Journal reference: Prostate-specific antigen at or before age 50 as a predictor of advanced prostate cancer diagnosed up to 25 years later: a case-control study. David Ulmert, Angel M Cronin, Thomas Bjork, Matthew F O'Brien, Peter T Scardino, James A Eastham, Charlotte Becker, Goran Berglund, Andrew J Vickers and Hans Lilja. BMC Medicine (in press)

The research was funded by grants from the National Cancer Institute, the Swedish Cancer Society, and the European Union Sixth Framework Program. Dr. Hans Lilja holds patents for free PSA and hK2 assays.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Memorial Sloan-Kettering Cancer Center. "Early Warning: PSA Testing Can Predict Advanced Prostate Cancer, Study Shows." ScienceDaily. ScienceDaily, 15 February 2008. <www.sciencedaily.com/releases/2008/02/080214191453.htm>.
Memorial Sloan-Kettering Cancer Center. (2008, February 15). Early Warning: PSA Testing Can Predict Advanced Prostate Cancer, Study Shows. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/02/080214191453.htm
Memorial Sloan-Kettering Cancer Center. "Early Warning: PSA Testing Can Predict Advanced Prostate Cancer, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/02/080214191453.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins