Featured Research

from universities, journals, and other organizations

Urinary Incontinence In Women: Gene Shows Its Strength In Pelvis

Date:
February 18, 2008
Source:
Journal of Clinical Investigation
Summary:
The quality of life of millions of women is negatively affected by pelvic organ prolapse, which causes symptoms such as urinary incontinence. In women with POP, the main supportive structures of the uterus and vagina, the uterosacral ligaments, are attenuated. Now, mouse studies have shown that the Hoxa11 gene makes a molecular factor essential for USL development, leading to the suggestion that changes in HOXA11-regulated pathways might weaken USLs and thereby cause POP.

The quality of life of millions of women is negatively affected by pelvic organ prolapse (POP) -- the downward descent of the pelvic organs that causes symptoms such as urinary incontinence.

In women with POP, the uterosacral ligaments (USLs), the main supportive structures of the uterus and vagina, are attenuated. Although changes in the content and quality of the collagen in the connective tissue of USLs have been associated with POP, no molecular mechanism(s) underlying this disorder has been described.

However, Kathleen Connell colleagues, at Yale University School of Medicine, New Haven, have now shown in mice that the protein encoded by the homeobox gene Hoxa11 is an essential molecular factor for the development of USLs, leading them to suggest that changes in HOXA11-regulated pathways might weaken the connective tissue of USLs and thereby cause POP.

In the study, mice lacking Hoxa11 were found to have no USLs and expression of HOXA11 was found to be markedly decreased in the USLs of women with POP. The USLs of women with POP also expressed decreased levels of the collagen type I and collagen type III genes as well as increased levels of the MMP2 gene that enables cells to generate a mediator of connective tissue degradation. Further in vitro analysis indicated that the mouse Hoxa11 gene increased expression of the collagen type III gene and decreased expression of the Mmp2 gene, thereby defining a molecular mechanism regulating the mechanical strength of USLs.

Journal article: HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse, Journal of Clinical Investigation. February 14, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Urinary Incontinence In Women: Gene Shows Its Strength In Pelvis." ScienceDaily. ScienceDaily, 18 February 2008. <www.sciencedaily.com/releases/2008/02/080215103305.htm>.
Journal of Clinical Investigation. (2008, February 18). Urinary Incontinence In Women: Gene Shows Its Strength In Pelvis. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2008/02/080215103305.htm
Journal of Clinical Investigation. "Urinary Incontinence In Women: Gene Shows Its Strength In Pelvis." ScienceDaily. www.sciencedaily.com/releases/2008/02/080215103305.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins