Featured Research

from universities, journals, and other organizations

Newly Discovered Role Of Thyroid Hormone During Pregnancy

Date:
February 23, 2008
Source:
Karolinska Institutet
Summary:
Thyroid hormone deficiencies in early pregnancy can cause locomotor underdevelopment in the child, according to new research. The results bring new insights into brain development and could affect routine pregnancy testing.

Thyroid hormone deficiencies in early pregnancy can cause locomotor underdevelopment in the child, according to research from the Swedish medical university Karolinska Institutet. The results bring new insights into brain development and could affect routine pregnancy testing.

Related Articles


Children born with thyroid hormone deficiencies (hypothyreosis) are in danger of mental and locomotor underdevelopment if they remain untreated. However, scientists are unsure about what causes the damage and about how much attention should be given to the mother's hormone levels during pregnancy. In Sweden, all newborn babies, but not all pregnant women, are tested for hypothyreosis.

Scientists at Karolinska Institutet have now shown in experiments on mice that both the mother's and the child's thyroid hormone are necessary for proper locomotor development. Hormone deficiencies during early pregnancy, when the mother is the only source of the hormone, produced locomotor disorders in the mice that persisted into adulthood, at which point they were beyond treatment.

"Hypothyreosis is easy to treat if it's discovered," says Professor Björn Vennström, who has led the study. "The results provide fresh support for those who advocate the more thorough monitoring of pregnant women."

The scientists were also able to show that the cause of the locomotor disorders was an abnormal development of specific nerve cells in the motor cortex and cerebellum. The findings thus give new and important insights into the part played by thyroid hormone in brain development.

The study used gene modified mice with a mutation in one of the two receptors for thyroid hormone. The discoveries mean that patients with mutations of the same receptor can, for the first time, be identified and treated.

Journal reference: 'Locomotor deficiencies and aberrant development of subtype-specific GABAergic interneurons caused by an unliganded thyroid hormone receptor alpha 1' Karin Wallis, Maria Sjögren, Max van Hogerlinden, Gilad Silberberg, André Fisahn, Kristina Nordström, Lars Larsson, Håkan Westerblad, Gabriela Morreale de Escobar, Oleg Shupliakov, Björn Vennström. Journal of Neuroscience, 20 February 2008


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Newly Discovered Role Of Thyroid Hormone During Pregnancy." ScienceDaily. ScienceDaily, 23 February 2008. <www.sciencedaily.com/releases/2008/02/080220091410.htm>.
Karolinska Institutet. (2008, February 23). Newly Discovered Role Of Thyroid Hormone During Pregnancy. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/02/080220091410.htm
Karolinska Institutet. "Newly Discovered Role Of Thyroid Hormone During Pregnancy." ScienceDaily. www.sciencedaily.com/releases/2008/02/080220091410.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins