Featured Research

from universities, journals, and other organizations

Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again

Date:
February 28, 2008
Source:
Indiana University
Summary:
Pediatric researchers report that treatment of eosinophilic esophagitis, an inflammatory condition known as EE that often mimics reflux and can cause refusal to eat, with oral or swallowed/sprayed steroids results in significant patient improvement, but that if discontinued relapse is common. EE affects one in 2,000 children.

Eosinophilic esophagitis, an inflammatory condition known as EE that often mimics reflux and can cause refusal to eat, affects about 1 in 2000 children in the United States and its prevalence is growing. Researchers from the Indiana University School of Medicine and Riley Hospital for Children report that treatment with oral or swallowed/sprayed steroids results in significant patient improvement, but that if discontinued relapse is common.

Related Articles


The results of a randomized clinical trial which compared prednisone and another commonly prescribed medication appears in the February 2008 issue of Clinical Gastroenterology and Hepatology.

EE can be a serious condition and cause children to refuse to eat, to vomit, or to get food stuck as the esophagus narrows from inflammation. EE, which does not improve without treatment, is twice as likely to occur in boys as in girls.

"We are seeing increasing numbers of children with EE who can benefit from effective therapy. Our study found that while systemic corticosteroids provided better initial patient improvement compared to swallowed steroids, long term results were similar between the groups," said Sandeep K. Gupta, M.D., IU School of Medicine associate professor of clinical pediatrics and a Riley Hospital pediatric gastroenterologist.

"A child will often continue to suffer in silence if this disease is left untreated. We are not sure why the number of cases is increasing, but we are seeing an average of two new cases every week at Riley Hospital. As we study treatment options, we are also investigating how and why food allergies and environmental factors appear to play a role in this disease," said Dr. Gupta.

The Clinical Gastroenterology and Hepatology study was supported by a Clarian Values Grant, Clarian Health, Indianapolis.

Journal reference: Clinical Gastroenterology and Hepatology 2008;6:165--173. Co-authors of the study are Elizabeth T. Schaeffer, M.D.; Joseph F. Fitzgerald, M.D.; Jean P. Molleston, M.D.; Joseph M. Croffie, M.D.; Marian D. Pfefferkorn, M.D.; Mark R. Corkins, M.D.; Joel D. Lim, M.D.; and Steven J. Steiner, M.D., all of the IU School of Medicine's Department of Pediatrics and Riley Hospital for Children's Division of Pediatric Gastroenterology.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again." ScienceDaily. ScienceDaily, 28 February 2008. <www.sciencedaily.com/releases/2008/02/080228100705.htm>.
Indiana University. (2008, February 28). Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2008/02/080228100705.htm
Indiana University. "Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again." ScienceDaily. www.sciencedaily.com/releases/2008/02/080228100705.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins