Featured Research

from universities, journals, and other organizations

Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again

Date:
February 28, 2008
Source:
Indiana University
Summary:
Pediatric researchers report that treatment of eosinophilic esophagitis, an inflammatory condition known as EE that often mimics reflux and can cause refusal to eat, with oral or swallowed/sprayed steroids results in significant patient improvement, but that if discontinued relapse is common. EE affects one in 2,000 children.

Eosinophilic esophagitis, an inflammatory condition known as EE that often mimics reflux and can cause refusal to eat, affects about 1 in 2000 children in the United States and its prevalence is growing. Researchers from the Indiana University School of Medicine and Riley Hospital for Children report that treatment with oral or swallowed/sprayed steroids results in significant patient improvement, but that if discontinued relapse is common.

The results of a randomized clinical trial which compared prednisone and another commonly prescribed medication appears in the February 2008 issue of Clinical Gastroenterology and Hepatology.

EE can be a serious condition and cause children to refuse to eat, to vomit, or to get food stuck as the esophagus narrows from inflammation. EE, which does not improve without treatment, is twice as likely to occur in boys as in girls.

"We are seeing increasing numbers of children with EE who can benefit from effective therapy. Our study found that while systemic corticosteroids provided better initial patient improvement compared to swallowed steroids, long term results were similar between the groups," said Sandeep K. Gupta, M.D., IU School of Medicine associate professor of clinical pediatrics and a Riley Hospital pediatric gastroenterologist.

"A child will often continue to suffer in silence if this disease is left untreated. We are not sure why the number of cases is increasing, but we are seeing an average of two new cases every week at Riley Hospital. As we study treatment options, we are also investigating how and why food allergies and environmental factors appear to play a role in this disease," said Dr. Gupta.

The Clinical Gastroenterology and Hepatology study was supported by a Clarian Values Grant, Clarian Health, Indianapolis.

Journal reference: Clinical Gastroenterology and Hepatology 2008;6:165--173. Co-authors of the study are Elizabeth T. Schaeffer, M.D.; Joseph F. Fitzgerald, M.D.; Jean P. Molleston, M.D.; Joseph M. Croffie, M.D.; Marian D. Pfefferkorn, M.D.; Mark R. Corkins, M.D.; Joel D. Lim, M.D.; and Steven J. Steiner, M.D., all of the IU School of Medicine's Department of Pediatrics and Riley Hospital for Children's Division of Pediatric Gastroenterology.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again." ScienceDaily. ScienceDaily, 28 February 2008. <www.sciencedaily.com/releases/2008/02/080228100705.htm>.
Indiana University. (2008, February 28). Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/02/080228100705.htm
Indiana University. "Treatment For Disease That Affects Estimated 1 In 2000 Children Gets Them To Eat Again." ScienceDaily. www.sciencedaily.com/releases/2008/02/080228100705.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins