Featured Research

from universities, journals, and other organizations

Advanced-stage Ovarian Cancer Patients With BRCA Live Longer, May Respond Better To Treatment, Study Shows

Date:
March 12, 2008
Source:
University of Texas M. D. Anderson Cancer Center
Summary:
Two abstracts underscoring the importance of testing for BRCA1/2 mutations in women with ovarian cancer have recently been presented. The majority of women with ovarian cancer are unaware BRCA testing is available.

Two abstracts underscoring the importance of testing for BRCA1/2 mutations in women with ovarian cancer were presented at this week's Society of Gynecologic Oncologists 39th Annual Meeting on Women's Cancers, by researchers from The University of Texas M. D. Anderson Cancer Center.

Related Articles


In the first study, a multicenter research team led by M.D. Anderson found advanced- stage ovarian cancer patients with non-Ashkenazi Jewish BRCA (non-AJ BRCA) mutations experience longer progression-free and overall survival rates compared to those with sporadic ovarian cancer. The data confirms previous research which reported that among ovarian cancer patients of Ashkenazi-Jewish heritage, BRCA1/2 mutations (AJ BRCA) are associated improved long-term survival.

For this study, researchers examined 85 advanced-stage ovarian cancer patients with non-AJ BRCA mutations and 116 patients who did not express any type of BRCA mutation. Compared to patients without BRCA mutations, non-AJ BRCA carriers had longer progression-free survival of 19.0 vs. 27.8 months and improved overall survival of 65.6 vs. 101.4 months. Non-AJ BRCA patients had a 2.15 times greater odds of complete response to initial chemotherapy response over sporadic, non-carrier patients.

Karen Lu, M.D., associate professor in the Department of Gynecologic Oncology at M. D. Anderson and senior author on the study said the difference in survival rates indicate that individuals with BRCA mutations might respond better to standard chemotherapy for ovarian cancer. "Thus, it becomes increasingly valuable to know a patient's BRCA status to guide and personalize treatment decisions," Lu said.

Majority of Patients Unaware BRCA Testing Available

A second study conducted at M. D. Anderson concluded that, despite being available for more than 10 years, a majority of women with ovarian cancer were unaware genetic counseling and testing for BRCA1/2 mutations was an option. Of the 225 ovarian cancer patients surveyed, 56 percent had not heard of BRCA testing. This lack of awareness was more profound in minorities - 69 percent of Hispanic and 88 percent of African American respondents were unaware of BRCA testing compared to 52 percent of white women.

"Patients typically associate genetic testing with benefiting family members and offspring," Lu said. "Both of these studies illustrate that it is equally important for the cancer patient to get information from their doctors about genetic testing because it not only has implications for their family, but their own treatment and prognosis."

She said that more than 85 percent of ovarian cancer patients surveyed would be willing to undergo BRCA testing if it would affect their care, but the cost of testing may be a barrier. "Currently, oncologists are inconsistent in their testing for BRCA mutations. Based on the treatment implications of our findings and the surprisingly low knowledge that such testing is available, we recommend developing ways to systematically evaluate every ovarian cancer patient for BRCA," Lu said.

A family history of breast and/or ovarian cancer is reported in approximately five percent to 15 percent of ovarian cancer cases, with BRCA1/2 mutations expressed in a significant proportion of these cases.

In addition to Lu, researchers contributing to the abstract on BRCA survival advantage include lead author Robin Lacour, M.D., Molly Daniels, M.S., Shannon Westin, M.D., Larissa Meyer, M.D., Charlotte Sun, Dr.P.H., Diana Urbauer, M.S., Pedro Ramirez, M.D., Diane Bodurka, M.D., David Gershenson, M.D., all of M. D. Anderson.

Others include Veena Choubey and Stephanie Blank, M.D., New York University Medical Center; Heather MacDonald, M.D. and Lynda Roman, M.D., University of Southern California Medical Center; Jacob Estes, M.D. and Mack Barnes, M.D., University of Alabama Birmingham; Deanna Teoh, M.D. and Beth Ann Powell, M.D., University of California at San Francisco Medical Center; Rebecca Brooks, M.D., David Mutch, M.D. and Sherri Babb, M.S., Washington University (St. Louis) Medical Center; Shana Wingo, M.D. and John Schorge, M.D., The University of Texas Southwestern Medical Center at Dallas.

On the BRCA genetic testing abstract, with Lu other authors include: Lacour, Kristin White, Molly Daniels, Shannon Westin, Larissa Meyer, Catherine Burke, W.H.N.P., Kimberly Burns, W.H.N.P., Shiney Kurian, W.H.N.P., Nicki.Webb, W.H.N.P., Terri Pustilnik, M.D., Diana Urbauer, Charlotte Sun, Diane Bodurka, David Gershenson of M. D. Anderson.


Story Source:

The above story is based on materials provided by University of Texas M. D. Anderson Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Texas M. D. Anderson Cancer Center. "Advanced-stage Ovarian Cancer Patients With BRCA Live Longer, May Respond Better To Treatment, Study Shows." ScienceDaily. ScienceDaily, 12 March 2008. <www.sciencedaily.com/releases/2008/03/080310155225.htm>.
University of Texas M. D. Anderson Cancer Center. (2008, March 12). Advanced-stage Ovarian Cancer Patients With BRCA Live Longer, May Respond Better To Treatment, Study Shows. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/03/080310155225.htm
University of Texas M. D. Anderson Cancer Center. "Advanced-stage Ovarian Cancer Patients With BRCA Live Longer, May Respond Better To Treatment, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/03/080310155225.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins