Featured Research

from universities, journals, and other organizations

Protein That Stimulates Fat Formation Discovered

Date:
March 13, 2008
Source:
Karolinska Institutet
Summary:
Scientists have discovered a protein that plays a fundamental part in the formation of new fat cells. The protein has a potential use in the treatment of obesity and cachexia (morbid weight loss). The discovery of the protein, which is called TRAP and which is secreted by immune cells in fat tissue, provides new insights into the chronic fat tissue inflammation that characterizes obesity.

Scientists at the Swedish medical university Karolinska Institutet have discovered a protein that plays a fundamental part in the formation of new fat cells. The protein has a potential use in the treatment of obesity and cachexia (morbid weight loss).

The discovery of the protein, which is called TRAP and which is secreted by immune cells in fat tissue, provides new insights into the chronic fat tissue inflammation that characterises obesity.

Using both cell cultures and mice studies, the researchers have shown that TRAP stimulates the formation of new fat cells and can thus precipitate the development of obesity. The results also show that patients with obesity have excessive levels of TRAP.

In malignant obesity, the fat cells are enlarged and less sensitive to insulin, which can lead to high glucose levels and type II diabetes. The scientists were able to show, however, that in mice TRAP gives rise to more benign fat cells of a normal size and metabolism.

"This protein is potentially useful in the treatment of conditions involving morbid cachexia, such as certain cancer diseases," says Professor G๖ran Andersson who has led the study with Professor Peter Arner. "The discovery can also lead to new ways pf treating obesity based on the inhibition of this protein s effect."

Journal reference: Pernilla Lๅng, Vanessa van Harmelen, Mikael Ryd้n, Maria Kaaman, Paolo Parini, Claes Carneheim, A Ian Cassady, David A Hume, G๖ran Andersson, Peter Arner. 'Monomeric Tartrate Resistant Acid Phosphatase Induces Insulin Sensitive Obesity.' PLoS One, 5 March 2008


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Protein That Stimulates Fat Formation Discovered." ScienceDaily. ScienceDaily, 13 March 2008. <www.sciencedaily.com/releases/2008/03/080311091637.htm>.
Karolinska Institutet. (2008, March 13). Protein That Stimulates Fat Formation Discovered. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2008/03/080311091637.htm
Karolinska Institutet. "Protein That Stimulates Fat Formation Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/03/080311091637.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins