Featured Research

from universities, journals, and other organizations

New Method Selects Eggs With Best Chance Of Leading To Successful Pregnancy

Date:
March 15, 2008
Source:
University of Laval
Summary:
Scientists have identified genetic markers that allow the selection of eggs with the best chance of leading to successful pregnancy after in vitro fertilization. This finding could both increase the success rate of single embryo transfer and diminish the risk of multiple pregnancies.

A research team supervised by Université Laval scientist Marc-André Sirard has identified genetic markers that allow the selection of eggs with the best chance of leading to successful pregnancy after in vitro fertilization (IVF). This finding could both increase the success rate of single embryo transfer and diminish the risk of multiple pregnancies. The details of the method developed by the researchers, for which an international patent application has been filed, are explained on the website of the scientific journal Human Reproduction.

Eggs recovered in the course of the IVF process are surrounded by follicular cells that are removed before the actual fertilization procedure begins. "While in the ovaries, these cells and the eggs are in very close interaction," explains Sirard. "A first experiment we conducted on bovine follicular cells led us to believe that these cells might possess specific markers that would be able to give us information about the quality of an egg."

With the help of 40 women recruited in a fertility clinic, researchers compared follicular cells surrounding eggs that ultimately led to successful pregnancies--i.e. "good" eggs--to cells surrounding ovules that did not result in pregnancy. This comparison led to the identification of five genes expressed more abundantly in follicular cells surrounding good eggs.

Currently, the way to assess which embryos are to be transferred into a woman's uterus is based on visible criteria such as appearance and division rate. "At least 30% of embryos that look normal through visual examination nonetheless show chromosome abnormalities," explains Professor Sirard, illustrating the limits of this type of assessment. The method developed by Sirard's team makes it possible to objectively select ovules that have the best chance of success without altering the integrity of the embryos.

This new genomic tool could also solve an ethical problem confronting both fertility clinic doctors and the people who consult them: In order to increase the chances of pregnancy, many embryos are implanted simultaneously into the woman in the hope that at least one will survive. This procedure along with improved IVF techniques has led to an increase in multiple pregnancies.

Even if doctors now tend to transfer fewer embryos, multiple pregnancies still occur in 30% of couples who resort to IVF in North America and 23% in European couples. "By selecting the embryo with the best potential, it would be possible to limit the number of embryos transferred, and thus the number of multiple pregnancies, while maintaining good success rates," concludes Marc-André Sirard.

In addition to Sirard, the study was co-authored by Mélanie Hamel, Isabelle Dufort, Claude Robert, and Catherine Gravel from Université Laval's Centre de recherche en biologie de la reproduction, as well as Marie-Claude Léveillée and Arthur Leader from the Ottawa Fertility Centre.


Story Source:

The above story is based on materials provided by University of Laval. Note: Materials may be edited for content and length.


Cite This Page:

University of Laval. "New Method Selects Eggs With Best Chance Of Leading To Successful Pregnancy." ScienceDaily. ScienceDaily, 15 March 2008. <www.sciencedaily.com/releases/2008/03/080312103801.htm>.
University of Laval. (2008, March 15). New Method Selects Eggs With Best Chance Of Leading To Successful Pregnancy. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2008/03/080312103801.htm
University of Laval. "New Method Selects Eggs With Best Chance Of Leading To Successful Pregnancy." ScienceDaily. www.sciencedaily.com/releases/2008/03/080312103801.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins