Featured Research

from universities, journals, and other organizations

Genes That Reduce 'Bad Cholesterol' And Protect Against Atherosclerosis Identified

Date:
March 17, 2008
Source:
Karolinska Institutet
Summary:
One way of combating atherosclerosis is to reduce levels of "bad cholesterol" in the blood. Scientists have now identified the genes that bring about this beneficial effect. Atherosclerosis is the main cause of myocardial infarction and stroke in Western nations.

One way of combating atherosclerosis is to reduce levels of "bad cholesterol" in the blood. Scientists at the Swedish medical university Karolinska Institutet have now identified the genes that bring about this beneficial effect.

Related Articles


In a new study on mice the research group has shown that the accumulation of the plaque that causes myocardial infarction and stroke can be prevented if levels of the "bad" LDL cholesterol are reduced before atherosclerotic plaque has progressed beyond a particular point. The group has also identified a network of 37 genes that lowers levels of blood cholesterol and brings about the beneficial effect.

"Previously, much atherosclerosis research was focused on identifying ways to stabilise the most dangerous plaques in order to prevent them rupturing and causing myocardial infarction or stroke," says Associate Professor Johan Björkegren, who has led the study. "Our discovery means that we can now target the actual development of dangerous plaques."

Rather than covering individual vessel wall genes, their discovery encompasses a network of genes, and one that explains their mutual interaction. It is on account of years of network algorithm development under Jesper Tegnér, professor of computational biology, that the discovery of gene networks has been made possible.

"The time when individual genes or gene pathways were thought to explain the development of complex common diseases, such as atherosclerosis, is past," says Dr Björkegren. "We now have enough tools and knowledge of system biology to take on the total complexity of these diseases."

Atherosclerosis is the main cause of myocardial infarction and stroke, which cause almost half of all deaths in Sweden and other countries in the West.

Publication: 'Transcriptional Profiling Uncovers a Network of Cholesterol-Responsive Atherosclerosis Target Genes', Josefin Skogsberg, Jesper Lundström, Alexander Kovacs, Roland Nilsson, Peri Noori, Shohreh Maleki, Marina Köhler, Anders Hamsten, Jesper Tegnér, Johan Björkegren, PLoS Genetics, 14 March 2008. (plosgenetics.org/doi/pgen.1000036)


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Genes That Reduce 'Bad Cholesterol' And Protect Against Atherosclerosis Identified." ScienceDaily. ScienceDaily, 17 March 2008. <www.sciencedaily.com/releases/2008/03/080314091645.htm>.
Karolinska Institutet. (2008, March 17). Genes That Reduce 'Bad Cholesterol' And Protect Against Atherosclerosis Identified. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2008/03/080314091645.htm
Karolinska Institutet. "Genes That Reduce 'Bad Cholesterol' And Protect Against Atherosclerosis Identified." ScienceDaily. www.sciencedaily.com/releases/2008/03/080314091645.htm (accessed October 24, 2014).

Share This



More Mind & Brain News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) — A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) — Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) — We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins