Featured Research

from universities, journals, and other organizations

Brain's 'Sixth Sense' For Calories Discovered

Date:
March 27, 2008
Source:
Cell Press
Summary:
The brain can sense the calories in food, independent of the taste mechanism, researchers have found in studies with mice. Their finding that the brain's reward system is switched on by this "sixth sense" machinery could have implications for understanding the causes of obesity. For example, the findings suggest why high-fructose corn syrup, widely used as a sweetener in foods, might contribute to obesity.

Mouse enjoying a sweet plum.
Credit: iStockphoto

The brain can sense the calories in food, independent of the taste mechanism, researchers have found in studies with mice. Their finding that the brain's reward system is switched on by this "sixth sense" machinery could have implications for understanding the causes of obesity. For example, the findings suggest why high-fructose corn syrup, widely used as a sweetener in foods, might contribute to obesity.

Ivan de Araujo and colleagues published their findings in the March 27, 2008, issue of the journal Neuron.

In their experiments, the researchers genetically altered mice to make them "sweet-blind," lacking a key component of taste receptor cells that enabled them to detect the sweet taste.

The researchers next performed behavioral tests in which they compared normal and sweet-blind mice in their preference for sugar solutions and those containing the noncaloric sweetener sucralose. In those tests, the sweet-blind mice showed a preference for calorie-containing sugar water that did not depend on their ability to taste, but on the calorie content.

In analyzing the brains of the sweet-blind mice, the researchers showed that the animals' reward circuitry was switched on by caloric intake, independent of the animals' ability to taste. Those analyses showed that levels of the brain chemical dopamine, known to be central to activating the reward circuitry, increased with caloric intake. Also, electrophysiological studies showed that neurons in the food-reward region, called the nucleus accumbens, were activated by caloric intake, independent of taste.

Significantly, the researchers found that a preference for sucrose over sucralose developed only after ten minutes of a one-hour feeding session and that neurons in the reward region also responded with the same delay.

"In summary, we showed that dopamine-ventral striatum reward systems, previously associated with the detection and assignment of reward value to palatable compounds, respond to the caloric value of sucrose in the absence of taste receptor signaling," concluded the researchers. "Thus, these brain pathways do not exclusively encode the sensory-related hedonic impact of foods, but might also perform previously unidentified functions that include the detection of gastrointestinal and metabolic signals," they wrote.

The scientific questions raised by the discovery of the brain's calorie-sensing system "are extremely important to understanding the pathogenesis and sociology of human obesity," wrote Zane Andrews and Tamas Horvath in a preview of the article in the same issue of Neuron.

"For example, high-fructose corn syrup is a ubiquitous sweetener in American society, and evidence suggests that fructose is not as effective as sucrose in terminating a meal. It may be that fructose produces stronger activation of the reward system and that removing high-fructose corn syrup as a sweetener will curb some desire for these products. Regardless, the present study alone will further galvanize the scientific community to understand how higher cognitive centers in the brain control food intake and body weight regulation," wrote Andrews and Horvath.

The researchers include Ivan E. de Araujo, Duke University Medical Center, Durham, NC; Albino J. Oliveira-Maia, Duke University Medical Center, Durham, NC, Universidade do Porto, Porto, Portugal; Tatyana D. Sotnikova, Duke University Medical Center, Durham, NC; Raul R. Gainetdinov, Duke University Medical Center, Durham, NC; Marc G. Caron, Duke University Medical Center, Durham, NC; Miguel A.L. Nicolelis, Duke University Medical Center, Durham, NC and Sidney A. Simon, Duke University Medical Center, Durham, NC.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Brain's 'Sixth Sense' For Calories Discovered." ScienceDaily. ScienceDaily, 27 March 2008. <www.sciencedaily.com/releases/2008/03/080326121239.htm>.
Cell Press. (2008, March 27). Brain's 'Sixth Sense' For Calories Discovered. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/03/080326121239.htm
Cell Press. "Brain's 'Sixth Sense' For Calories Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/03/080326121239.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins