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New Method To Test For Lung Cancer Developed

Date:
April 4, 2008
Source:
Boston University
Summary:
Researchers have developed a new "clinicogenomic model" to accurately test for lung cancer. The model combines a specific gene expression for lung cancer as well as clinical risk factors.

Researchers from Boston University School of Medicine have developed a new 'clinicogenomic model' to accurately test for lung cancer. The model combines a specific gene expression for lung cancer as well as clinical risk factors. These findings currently appear on-line in the journal Cancer Prevention Research.

Lung cancer is the leading cause of cancer death in the United States and the world, with more than one million deaths worldwide annually. Eighty-five to 90 percent of subjects with lung cancer in the United States are current or former smokers with 10 to 20 percent of heavy smokers developing this disease.

A previous study by the same researchers reported a gene expression biomarker capable of distinguishing cytologically normal large airway epithelial cells from smokers with and without lung cancer. However, the biomarker has limited sensitivity depending on the stage and the location of the cancer.

Studying current and former smokers undergoing bronchoscopies for suspicion of lung cancer, the researchers compared the likelihood of the subjects having lung cancer using the biomarker, the clinical risk factors and a combination of the two -- clinicogenomic model. They found patients using the clinicogenomic model had increased sensitivity, specificity, positive value and negative predictive value of their cancer compared to the other methods.

"Our data suggests that the clinicogenomic model might serve to identify patients who would benefit from further invasive testing, thereby expediting the diagnosis and treatment for their malignancy," said senior author Avrum Spira, MD, an assistant professor of medicine and pathology at Boston University School of Medicine.

According to the researchers, it is hoped this prediction model will expedite more invasive testing and appropriate therapies for smokers with lung cancer as well as reduce invasive diagnostic procedures for individuals without lung cancer.

Funding for this study was provided by the Doris Duke Charitable Foundation and National Institutes of Health and National Cancer Institute grants.

Spira is a pulmonary and critical care medicine physician at Boston Medical Center and is one of the founders of Allegro Diagnostics Inc., a molecular diagnostics company that plans to market the gene expression biomarker.


Story Source:

The above story is based on materials provided by Boston University. Note: Materials may be edited for content and length.


Cite This Page:

Boston University. "New Method To Test For Lung Cancer Developed." ScienceDaily. ScienceDaily, 4 April 2008. <www.sciencedaily.com/releases/2008/04/080401141545.htm>.
Boston University. (2008, April 4). New Method To Test For Lung Cancer Developed. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2008/04/080401141545.htm
Boston University. "New Method To Test For Lung Cancer Developed." ScienceDaily. www.sciencedaily.com/releases/2008/04/080401141545.htm (accessed October 23, 2014).

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