Featured Research

from universities, journals, and other organizations

Stem Cells And Cancer: Scientists Investigate A Fine Balancing Act

Date:
April 14, 2008
Source:
Biotechnology and Biological Sciences Research Council
Summary:
The mechanisms normally involved in balancing different functions of stem cells may also contribute to cancer. Scientists are delving into these mechanisms to understand how stem cells are normally regulated, and what role they may play in malignant brain tumors.

Speaking at the UK National Stem Cell Network Annual Science Meeting in Edinburgh, on April 11, Professor Silvia Marino shows how the mechanisms normally involved in balancing different functions of stem cells may also contribute to cancer. Her team from Barts and the London School of Medicine and Dentistry is currently delving into these mechanisms to understand how stem cells are normally regulated and what role they may play in malignant brain tumours.

Professor Marino said: "Stem cells are present in the adult brain where they normally play a role in repair and regeneration. We want to know whether brain cancer can originate from problems in the regulation of these cells. Moreover, it is becoming increasingly clear that tumours maintain themselves with mechanisms similar to the ones used by stem cells. We want to understand whether differences can be identified between normal stem cells and cancer stem cells. If this is the case, new drugs can be developed to specifically kill the cells maintaining and propagating the tumour without harming normal stem cells."

In the body it is vital that a balance is struck between maintaining numbers of stem cells with making new stem cell derived tissues. This is important in embryonic development and also in preserving healthy adult tissues. If the balance is wrong then disease can arise. Cancer can result from stem cells dividing too much, leading to an excess of new cells. But if stem cells do not divide to replenish the stocks for renewal and repair then the result can be ageing and possibly degenerative diseases.

Professor Marino's group works to identify the mechanisms involved in maintaining this balance and assess whether similar mechanisms can possibly contribute to the formation and maintenance of malignant brain tumours. For example, research to date shows that a gene called Bmi1 is important for maintaining stocks of stem cells and without it the stocks of stem cells are depleted. And importantly this gene is overactive in various cancers including brain tumours.

This work has been funded by Cancer Research UK, Oncosuisse, Barts and the London Charity, Ali's Dream and Charlie's Challenge.


Story Source:

The above story is based on materials provided by Biotechnology and Biological Sciences Research Council. Note: Materials may be edited for content and length.


Cite This Page:

Biotechnology and Biological Sciences Research Council. "Stem Cells And Cancer: Scientists Investigate A Fine Balancing Act." ScienceDaily. ScienceDaily, 14 April 2008. <www.sciencedaily.com/releases/2008/04/080411101941.htm>.
Biotechnology and Biological Sciences Research Council. (2008, April 14). Stem Cells And Cancer: Scientists Investigate A Fine Balancing Act. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2008/04/080411101941.htm
Biotechnology and Biological Sciences Research Council. "Stem Cells And Cancer: Scientists Investigate A Fine Balancing Act." ScienceDaily. www.sciencedaily.com/releases/2008/04/080411101941.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins