Featured Research

from universities, journals, and other organizations

Parkinson Transplants Survive At Least 16 Years

Date:
April 13, 2008
Source:
Lund University
Summary:
Transplanted cells to help Parkinson's patients can survive in the brain for over one and half decades. However, some of the transplanted cells developed Parkinson-like features which is very surprising. These are the main findings of a study on grafting of new neurons to the brain in patients with Parkinson's disease. 'Previous studies have shown that transplanted dopamine cells can clearly improve speed of movement, reduce rigidity and the need for medication for at least a decade', says a Neurobiology professor involved with the research. 'We now see that they also are alive in large numbers, which is very exciting.'

Transplanted cells to help patients with Parkinson's disease can survive in the brain for over one and half decades. However, some of the transplanted cells developed Parkinson-like features which is very surprising. These are the main findings of a study on grafting of new neurons to the brain in patients with Parkinson’s disease. The study, headed by a team of researchers from Lund University in collaboration with London scientists, has been published in a recent issue of Nature Medicine.

'Previous studies have shown that transplanted dopamine cells can clearly improve speed of movement, reduce rigidity and the need for medication for at least a decade', says Jia-Yi Li, Associate Professor of Neurobiology, Neuronal Survival Unit at Lund University. 'We now see that they also are alive in large numbers, which is very exciting.'

However, in addition to the long-term survival of transplanted neurons, the scientists also found that Parkinson’s disease changes may appear inside a graft. This suggests that the disease mechanism is able to transfer gradually from a sick to a healthy cell in the brain.

'Our results suggest that key features of Parkinson's disease pathology slowly transfer from the patient’s brains to the healthy nerve cells in the transplant', says Patrik Brundin, Professor of Neuroscience and Head of the Neuronal Survival Unit at Lund University.

'We still do not know the precise cellular mechanisms, but the findings open up new exciting lines of research. If we can crack the mechanism, we may be able to devise treatments that prevent or slow disease progression in the future.'

The research group at Lund University and Lund University Hospital has earlier shown that the transplanted cells are functional for a decade. The new findings, that extend the survival time even further, mean that cell therapy is still a viable possibility.

'Although we have now found that the grafted cells may be affected by the disease, the pathological changes appear late. In my view transplantation of dopamine cells, probably generated from stem cells, therefore remains a promising and important novel strategy for the treatment of patients with Parkinson’s disease', says Olle Lindvall, Professor of Neurology at Lund University Hospital.

Journal reference: Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation, Nature Medicine. Published online: 6 April 2008 | doi:10.1038/nm1746


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Cite This Page:

Lund University. "Parkinson Transplants Survive At Least 16 Years." ScienceDaily. ScienceDaily, 13 April 2008. <www.sciencedaily.com/releases/2008/04/080412112931.htm>.
Lund University. (2008, April 13). Parkinson Transplants Survive At Least 16 Years. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2008/04/080412112931.htm
Lund University. "Parkinson Transplants Survive At Least 16 Years." ScienceDaily. www.sciencedaily.com/releases/2008/04/080412112931.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins