Featured Research

from universities, journals, and other organizations

Gender-related Differences Found In Development Of Colon Cancer

Date:
April 17, 2008
Source:
University of Southern California
Summary:
A new study has found evidence that supports gender-related differences in the development and survival of metastatic colon cancer. Specific gene variants linked to the development of colon cancer resulted in opposite survival outcomes for men and women.

A new study by researchers at the University of Southern California (USC) has found evidence that supports gender-related differences in the development and survival of metastatic colon cancer.

Related Articles


The study, which will be published in the April 15 issue of the journal Cancer Research, found that specific gene variants linked to the development of colon cancer resulted in opposite survival outcomes for men and women.

Germline variations in the epidermal growth factor receptor (EGFR) DNA -- a gene widely expressed in colonic tissue -- has been linked with poor prognosis in colon cancer, says Oliver Press, an M.D. student at the Keck School of Medicine of USC and lead author of the study. However, when researchers looked at EGFR as a prognostic factor, they found that it had opposite implications for men and women.

"We expected to find that high expression would correlate with a poor prognosis and faster growth of the cancer," says Press. "What we found was that men followed the expected trend, while women's response was the opposite."

Researchers analyzed 318 patients -- 177 men and 141 women -- with metastatic colon cancer treated at the USC/Norris Comprehensive Cancer Center and the LAC+USC Medical Center between 1992 and 2003. All the patients were exposed to similar chemotherapy treatments. When genomic DNA samples were analyzed, researchers found that women who had specific gene variants linked with high expression of EGFR had higher overall survival rates, while men with the same variants had lower survival.

"This is the first report to show that the prognostic value of EGFR depends on gender," says Heinz-Josef Lenz, M.D., professor of medicine at the Keck School of Medicine and the principal investigator on the study. "This may suggest that, in the future, molecular markers should be evaluated differently in women and men and that treatment decisions may depend on gender and not only on molecular or clinical findings."

Previous research has shown a protective effect of female hormones in colon cancer survival, Press notes. The findings of the study indicate that hormone receptors are important to signal pathways related to the survival of patients.

The study is an important jumping off point to further research into how men and women differ in response to specific treatments, he says.

"Research will need to be done to determine whether women and men respond differently to certain cancer therapies," Press says. "Down the road we may see targeted chemotherapy that is tailored to get the best response from male and female patients."

The study was supported by grants from the National Institutes of Health, the San Pedro Guild Research Fund and Charles Bittick.

Journal reference: Oliver A. Press, Wu Zhang, Michael A. Gordon, Dongyun Yang, Georg Lurje, Syma Iqbal, Anthony El-Knoueiry and Heinz-Josef Lenz., "Gender-Related Survival Differences Associated with Epidermal Growth Factor Receptor Polymorphisms in Metastatic Colon Cancer." Cancer Research, April 15, 2008. Doi:10.1158/0008-5472.CAN-07-2718.


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University of Southern California. "Gender-related Differences Found In Development Of Colon Cancer." ScienceDaily. ScienceDaily, 17 April 2008. <www.sciencedaily.com/releases/2008/04/080415101024.htm>.
University of Southern California. (2008, April 17). Gender-related Differences Found In Development Of Colon Cancer. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/04/080415101024.htm
University of Southern California. "Gender-related Differences Found In Development Of Colon Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/04/080415101024.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins