Featured Research

from universities, journals, and other organizations

Breakthrough In Migraine Genetics: Genomic Locus Of Migraine Susceptibility Found

Date:
April 21, 2008
Source:
University of Helsinki
Summary:
Scientists have, for the first time, convincingly demonstrated a genomic locus linked to migraine susceptibility in two diverse populations. Migraine is the most common cause of episodic headache, and by far the most common neurological cause of a doctor's visit. It affects some 15% of the population, including some 41 million people in Europe, and places a considerable burden on healthcare in both the developed and the developing world.

In a new study, published in the American Journal of Human Genetics, researchers were able for the first time to convincingly demonstrate a genomic locus to be linked to migraine susceptibility in two diverse populations. "This study gives new hope to deciphering the migraine pathways and therefore discovering targets for future treatments, as well as discovering the first migraine gene variants," says professor Aarno Palotie from the University of Helsinki, Finland.

Migraine is the most common cause of episodic headache, and by far the most common neurological cause of a doctor's visit. It affects some 15% of the population, including some 41 million people in Europe, and places a considerable burden on healthcare in both the developed and the developing world.

During the last few years, great strides have been made in discovering common genes influencing the susceptibility to common diseases, such as diabetes, Crohn's disease and schizophrenia. However, no genes have yet been convincingly associated with migraine susceptibility, probably due to the high degree of variability of the disease phenotype combined with the lack of viable laboratory tests.

"To address this problem, we developed a new analysis technique concentrating on different symptoms of migraine", says Professor Aarno Palotie (University of Helsinki, Finland, and the Sanger Institute, Cambridge, UK). The new technique was used in the large international study including 1700 migraine patients and their close relatives from 210 Finnish and Australian migraine families. The Finnish families had been ascertained through neurology clinics, while the Australian families had been collected through a twin study. An initial genome-wide microsatellite study was followed up by an independent targeted replication study.

Researchers identified one gene locus on chromosome 10q23, which showed significant evidence of genetic linkage in both populations studied as well as in the replication study. The gene locus was especially strongly linked to female migraineurs. "In a further analysis, two independent previous studies, one Finnish and one Australian, had detected the same locus, but in those studies the level of evidence had been just below significance, and thus the connection had so far been missed", tells researcher Verneri Anttila from Palotie's group.

This locus is thus linked to migraine in a total of 4000 migraineurs or their close relatives. "All of these findings depended on the newly discovered aspect of migraine genetics: different types of pain -- such as pain that pulsates or pain that is unilateral -- are more closely linked to specific genetic loci than general pain", Palotie states.

In this study, researchers were able for the first time to convincingly demonstrate a genomic locus to be linked to migraine susceptibility in two diverse populations. This is especially interesting as Finland and Australia are genetically distant, and also as it tied together previous research, resulting in very robust evidence for pinpointing the susceptibility region.

"This study is the first international collaboration as well as the largest linkage study in migraine to date. It successfully applied new analysis strategies in detecting the locus and thus paved the way for subsequent large association studies", Palotie and Anttila say. According them, this study gives new hope to deciphering the migraine pathways and therefore discovering targets for future treatments, as well as discovering the first migraine gene variants.


Story Source:

The above story is based on materials provided by University of Helsinki. Note: Materials may be edited for content and length.


Cite This Page:

University of Helsinki. "Breakthrough In Migraine Genetics: Genomic Locus Of Migraine Susceptibility Found." ScienceDaily. ScienceDaily, 21 April 2008. <www.sciencedaily.com/releases/2008/04/080417095932.htm>.
University of Helsinki. (2008, April 21). Breakthrough In Migraine Genetics: Genomic Locus Of Migraine Susceptibility Found. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2008/04/080417095932.htm
University of Helsinki. "Breakthrough In Migraine Genetics: Genomic Locus Of Migraine Susceptibility Found." ScienceDaily. www.sciencedaily.com/releases/2008/04/080417095932.htm (accessed April 23, 2014).

Share This



More Mind & Brain News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
Do We Get Nicer With Age?

Do We Get Nicer With Age?

Newsy (Apr. 22, 2014) A recent report claims personality can change over time as we age, and usually that means becoming nicer and more emotionally stable. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins