Featured Research

from universities, journals, and other organizations

Genotyping Takes Us Closer To An Osteoporosis Fingerprint

Date:
May 1, 2008
Source:
Garvan Institute for Medical Research
Summary:
For the first time ever, an extensive genome-wide search has been undertaken to find the genes linked to osteoporosis and fracture. Five regions of interest have been identified that appear to warrant further scientific investigation.

For the first time ever, an extensive genome-wide search has been undertaken to find the genes linked to osteoporosis and fracture. Five regions of interest have been identified that appear to warrant further scientific investigation.

From the age of 60, 40% women and 25% men will sustain a fracture due to osteoporosis, with the risk being higher in people with a family history of fracture. There are 30,000 genes in the human genome, but until now few have been unequivocally linked to osteoporosis and fragility fractures.

The Garvan Institute for Medical Research collaborated with the Icelandic genetics company, deCode, in a project that looked at 1500 women from Garvan's Dubbo Osteoporosis Epidemiology Study as well as more than 12,000 women from Iceland and Denmark.

"Genome-wide genotyping, a very demanding and labour-intensive procedure, measures genetic variations called 'Snips' (SNPs or single nucleotide polymorphisms), within each of our 30,000 genes," said Garvan's Associate Professor Tuan Nguyen, who has been involved with the Dubbo project over a period of nearly 20 years. "The collaborative study examined more than 300,000 such markers and found 12 that were linked to bone mineral density and 6 linked to fragility fractures. Some of these Snips are close to genes that are already known to be associated with osteoporosis."

Professor John Eisman, Head of Garvan's Bone Program, is very pleased with these findings. "This international study and the access to the information it brings is a positive example of the value of world-wide scientific collaborations in the area of human genetics. The study identified a number of regions in the human genome that are already known to be important in bone biology, while others are yet to be investigated," he said.

"The next step will be identifying what those genes are and how they might contribute to our understanding of osteoporosis and its prevention. This is an important example of Australian science participating in international science at the highest level."

The discovery of genes linked to osteoporosis will allow researchers to better develop prognostic models, and help clinicians identify individuals with high risk of fracture for intervention.

The results of this multi-nation study are reported in a paper appearing online April 30 in the New England Journal of Medicine.


Story Source:

The above story is based on materials provided by Garvan Institute for Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Garvan Institute for Medical Research. "Genotyping Takes Us Closer To An Osteoporosis Fingerprint." ScienceDaily. ScienceDaily, 1 May 2008. <www.sciencedaily.com/releases/2008/04/080430091115.htm>.
Garvan Institute for Medical Research. (2008, May 1). Genotyping Takes Us Closer To An Osteoporosis Fingerprint. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2008/04/080430091115.htm
Garvan Institute for Medical Research. "Genotyping Takes Us Closer To An Osteoporosis Fingerprint." ScienceDaily. www.sciencedaily.com/releases/2008/04/080430091115.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins