Featured Research

from universities, journals, and other organizations

Double Life Of Proteins Discovered

Date:
May 1, 2008
Source:
Australian National University
Summary:
Scientists are a step closer to understanding the rare Hartnup disorder after discovering a surprising link between blood pressure regulation and nutrition that could also help to shed light on intestinal and kidney function.

Scientists at The Australian National University are a step closer to understanding the rare Hartnup disorder after discovering a surprising link between blood pressure regulation and nutrition that could also help to shed light on intestinal and kidney function.

Related Articles


The team from the University's School of Biochemistry and Molecular Biology together with colleagues from the University of Sydney set out to study nutrient uptake in the intestine and discovered an essential role of a protein called ACE2 in the process. ACE proteins cut off a small part of a precursor molecule generating a hormone, which regulates blood pressure. ACE inhibitors are widely prescribed drugs that reduce the risk of heart failure and protect against the long-term effects of diabetes.

Two versions of the protein are known as ACE1 and ACE2. ACE1 is targeted by the blood pressure reducing drugs, but until now the role of ACE2 has been less clear. What the researchers found was a completely different role for ACE2 in nutrition.

"Protein forms up to 20 per cent of our nutrition," said one of the authors of the report, Professor Stefan Brφer. "Before it can be used by the human body, protein is split into its subunits called amino acids. The amino acids are then removed from the intestine by specialised cells which are endowed with a large number of transporters moving nutrients from the intestine into cell.

"Instead of tailoring a specific hormone, ACE2 cuts into proteins releasing amino acids from the intestine into cells. Additionally, we found that ACE2 was also important to endow the cell with transporters" he said.

The research shows that a failure of certain transporters to make contact with ACE2 can cause Hartnup disorder -- where amino acid absorption in the intestine is impaired resulting in neurological problems and a skin rash in children.

The paper, published inThe Federation of American Societies for Experimental Biology (FASEB) Journal, also highlights the variety of roles that proteins can play.

"The results demonstrate a connection between blood pressure regulation and nutrition and also show that proteins in the body can serve several functions. This explains why drugs can have surprising side effects if the target carries out several functions.

"The results of this study will help understanding intestinal and kidney function, which are affected in common disorders such as diabetes and celiac disorder," said Professor Brφer.


Story Source:

The above story is based on materials provided by Australian National University. Note: Materials may be edited for content and length.


Cite This Page:

Australian National University. "Double Life Of Proteins Discovered." ScienceDaily. ScienceDaily, 1 May 2008. <www.sciencedaily.com/releases/2008/04/080430091118.htm>.
Australian National University. (2008, May 1). Double Life Of Proteins Discovered. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2008/04/080430091118.htm
Australian National University. "Double Life Of Proteins Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/04/080430091118.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) — A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) — An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) — A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) — If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins