Featured Research

from universities, journals, and other organizations

Naturally-occuring Protein May Be Effective In Limiting Heart Attack Injury And Restoring Function

Date:
May 7, 2008
Source:
Medical College of Wisconsin
Summary:
Researchers have shown for the first time that thrombopoietin, a naturally occurring protein being developed as a pharmaceutical to increase platelet count in cancer patients during chemotherapy, can also protect the heart against injury during a heart attack. Currently there are no therapies available to directly protect the heart against the damaging effects of a heart attack. The study was published in Cardiovascular Research.

Medical College of Wisconsin researchers in Milwaukee have shown for the first time that thrombopoietin (TPO), a naturally occurring protein being developed as a pharmaceutical to increase platelet count in cancer patients during chemotherapy, can also protect the heart against injury during a heart attack.

Related Articles


The study, led by John E. Baker PhD, professor of pediatric surgery in the division of cardiothoracic surgery, was published in the January 2008 issue of Cardiovascular Research. The importance of these findings was underscored in an accompanying editorial.

Currently there are no therapies available to directly protect the heart against the damaging effects of a heart attack. Dr. Baker's team has shown that administering a single dose of TPO to rats during a heart attack decreased the extent of permanent muscle damage to the heart and increased the ability of the heart to function afterwards, when compared with no drug treatment. Additionally, they found that a single cardioprotective treatment with TPO did not increase platelet count. This novel finding suggests the cardioprotective actions of TPO are separate from its ability to increase platelet count.

Dr. Baker has submitted a US and worldwide patent application on the tissue protective properties of TPO. Dr. Baker's discovery is licensed to Cardiopoietis, a Wisconsin LLC, formed to develop drugs for the treatment of heart attacks.

TPO is a hormone which is naturally produced by the liver and kidney. Dr. Baker's investigative team had previously shown that erythropoietin, a protein and pharmaceutical currently in clinical use to treat anemia in end-stage kidney disease, protects the rat heart against injury during a heart attack. They found that although erythropoietin and TPO have separate functional roles, there were similarities in the structures of the two proteins that suggested TPO may have protective properties similar to erythropoietin.

"We hypothesized that a single treatment with TPO during a heart attack would be sufficient to protect the heart from injury," says Dr. Baker. "Our results suggest that TPO directly protects the heart and may represent a novel approach for the treatment of acute heart attack."

The study was supported by a grant from the National Institutes of Health, National Heart, Lung and Blood Institute.

Co-authors of the study included Jidong Su, research associate of cardiothoracic surgery at the Medical College of Wisconsin; Anna Hsu, research associate of pharmacology and toxicology; Yang Shi, Ph.D., assistant professor of surgery; Ming Zhao, Ph.D., assistant professor of biophysics; Jennifer Strande, M.D., PhD instructor in Cardiovascular Medicine; Xiangping Fu, Research Technologist of surgery; Hao Xu, research scientist of surgery; Annie Eis, research associate of pediatrics; Richard Komorowski, M.D., professor of pathology; Eric Jensen, D.V.M., staff veterinarian at the Biomedical Resource Center; James Tweddell, M.D., professor and chief of cardiothoracic surgery; Parvaneh Rafiee, Ph.D., associate professor of surgery; and Garrett Gross, Ph.D., professor of pharmacology and toxicology.


Story Source:

The above story is based on materials provided by Medical College of Wisconsin. Note: Materials may be edited for content and length.


Cite This Page:

Medical College of Wisconsin. "Naturally-occuring Protein May Be Effective In Limiting Heart Attack Injury And Restoring Function." ScienceDaily. ScienceDaily, 7 May 2008. <www.sciencedaily.com/releases/2008/05/080506165531.htm>.
Medical College of Wisconsin. (2008, May 7). Naturally-occuring Protein May Be Effective In Limiting Heart Attack Injury And Restoring Function. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2008/05/080506165531.htm
Medical College of Wisconsin. "Naturally-occuring Protein May Be Effective In Limiting Heart Attack Injury And Restoring Function." ScienceDaily. www.sciencedaily.com/releases/2008/05/080506165531.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins