Featured Research

from universities, journals, and other organizations

Common Drug Halts Lung Damage In Emphysema, Study Shows

Date:
May 15, 2008
Source:
University of Leeds
Summary:
An antibiotic commonly used to treat acne can prevent tissue damage caused by lung diseases such as emphysema, researchers have found. It appears to boost the body's ability to protect against damage to the lungs.

An antibiotic commonly used to treat acne can prevent tissue damage caused by lung diseases such as emphysema, researchers have found.

A team of researchers from the Universities of Leeds and California, San Diego, studying a protein called VEGF have found that doxycyline - used to treat common ailments such as acne, sinusitis and urinary tract infections -- also boosts the body's ability to protect against damage to the lungs.

VEGF helps to maintain healthy lung tissue and emphysema sufferers are found to have unusually low levels of the protein. Dr Harry Rossiter from Leeds' Faculty of Biological Sciences explains: "In healthy people, the lungs have an active restorative system keeping them healthy, but in some lung diseases, the body's natural protective processes are inhibited, partly as a result of low levels of the VEGF protein."

In experiments, Dr Rossiter and his US colleagues reduced the levels of VEGF in the lungs of mice whilst simultaneously administering doxycycline. The researchers found that lung damage was minimal in these mice, compared with the control group which was not treated with the drug.

Ellen C Breen PhD from the School of Medicine at the University of California, San Diego says: "The images that we have of the lungs of mice that have been treated with doxycycline are startlingly different to those that we didn't treat. VEGF-deficient lungs show vast pockets of tissue damage when untreated and greatly reduced damage when treated with doxycycline."

The next step for research team is to try similar experiments with different drugs, with a view to trying to find one that will help the body rebuild lung tissue that has already died.

Dr Breen stresses that whilst the experiments show that doxycycline clearly has a role to play in preventing lung tissue damage, it is too early to say whether these findings would have a preventative role for humans with a genetic predisposition to lung disease.

"It's also important to remember that we were treating the mice with the drug whilst inducing the symptoms of lung disease, so this is by no means a cure," she says.

This research was funded by the Worldwide Universities Network and the US based Tobacco Related Disease Research Program and the findings are published in the current issue of the Journal of Cellular Biochemistry.


Story Source:

The above story is based on materials provided by University of Leeds. Note: Materials may be edited for content and length.


Cite This Page:

University of Leeds. "Common Drug Halts Lung Damage In Emphysema, Study Shows." ScienceDaily. ScienceDaily, 15 May 2008. <www.sciencedaily.com/releases/2008/05/080514213419.htm>.
University of Leeds. (2008, May 15). Common Drug Halts Lung Damage In Emphysema, Study Shows. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/05/080514213419.htm
University of Leeds. "Common Drug Halts Lung Damage In Emphysema, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/05/080514213419.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins