Featured Research

from universities, journals, and other organizations

Current Regenerative Medical Techniques Hold Great Promise For Bladder Regeneration

Date:
May 17, 2008
Source:
American Urological Association
Summary:
Bladder regeneration via a neo-bladder replacement may prove to be effective in humans.

Bladder regeneration via a neo-bladder replacement may prove to be effective in humans. The results of a new study, conducted in large mammals, presented May 15 at the 103rd Annual Scientific Meeting of the American Urological Association (AUA), suggest that this process could result in a regenerated bladder with similar characteristics of the native bladder and without the risks associated with a donated organ or other undesirable outcomes associated with current surgical interventions.

Researchers are from Tengion, Inc., whose science and technology facility is located in Winston-Salem, NC.

Patients with advanced bladder disease often require cystectomy (removal of the bladder). Replacement bladders made from intestinal tissue have been proven to be successful but have also been associated with many well documented complications, such as chronic urinary retention, hematuria and infection.

Growing a replacement organ for a patient using his or her own cells presents a new option. After a bladder biopsy is obtained from a patient, bladder progenitor cells are grown in culture and seeded on a biodegradable bladder-shaped scaffold made from collagen and/or polyglycolic acid. The neo-organ is then implanted into the patient.

Fourteen large mammals that underwent radical cystectomy were implanted with the neo-bladder construct and within six months, structure and pharmacological characteristics of the neo-bladder were similar to the native bladder. There was no evidence of abnormal tissue development, immune response or evidence of systemic response to the neo-bladder regeneration. Results suggest that the new organ had successfully and safely regenerated.

“This treatment option essentially regenerates the patient’s own bladder, reducing the risk of rejection and the need for immunosuppressant drugs,” said Timothy Bertram, D.V.M., Ph.D. “If successful in human clinical trials, patients should expect to regenerate normal bladder structure and function.”


Story Source:

The above story is based on materials provided by American Urological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bertram TA, Christ GJ, Aboushwareb TA, Wagner BJ, Jain D, Ludlow JW et al: Total regenerated urinary bladders are structurally and pharmacologically similar to native tissue. J Urol, suppl., 2008; 179:76, abstract 215. [link]

Cite This Page:

American Urological Association. "Current Regenerative Medical Techniques Hold Great Promise For Bladder Regeneration." ScienceDaily. ScienceDaily, 17 May 2008. <www.sciencedaily.com/releases/2008/05/080515072923.htm>.
American Urological Association. (2008, May 17). Current Regenerative Medical Techniques Hold Great Promise For Bladder Regeneration. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/05/080515072923.htm
American Urological Association. "Current Regenerative Medical Techniques Hold Great Promise For Bladder Regeneration." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515072923.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins