Featured Research

from universities, journals, and other organizations

Link Between Vitamin D Status And Breast Cancer Illuminated

Date:
May 16, 2008
Source:
University of California - San Diego
Summary:
Using newly available data on worldwide cancer incidence, researchers have shown a clear association between deficiency in exposure to sunlight, specifically ultraviolet B, and breast cancer.

Using newly available data on worldwide cancer incidence, researchers at the Moores Cancer Center at University of California, San Diego (UCSD) and the Department of Family and Preventive Medicine have shown a clear association between deficiency in exposure to sunlight, specifically ultraviolet B (UVB), and breast cancer.

UVB exposure triggers photosynthesis of vitamin D3 in the body. This form of vitamin D also is available through diet and supplements.

Approximately 1,150,000 cases and 410,000 deaths from breast cancer occur annually worldwide, including 215,000 new cases and 41,000 deaths in the United States.

"This is the first study, to our knowledge, to show that higher serum levels of vitamin D are associated with reduced incidence rates of breast cancer worldwide," said Cedric F. Garland, Dr. P.H., professor of Family and Preventive Medicine in the UCSD School of Medicine, and member of the Moores UCSD Cancer Center.

This paper used worldwide data only recently available through a new tool called GLOBOCAN, developed by the World Health Organization's International Agency for Research on Cancer. GLOBOCAN is a database of cancer incidence, mortality and prevalence for 175 countries.

The researchers created a graph with a vertical axis for breast cancer incidence rates, and a horizontal axis for latitude. The latitudes range from -50 for the southern hemisphere, to zero for the equator, to +70 for the northern hemisphere. They then plotted age-standardized incidence rates for 175 countries according to latitude. The resulting chart was a parabolic curve that looks like a smile.

"In general, breast cancer incidence was highest at the highest latitudes in both hemispheres," said Garland. "Even after controlling for known variables such as meat, vegetable and alcohol intake, cigarette consumption, weight, fertility and others, the inverse association of modeled vitamin D status with breast cancer incidence remained strong."

In the paper, the authors caution that this was a study of aggregates, or countries, rather than individuals; findings that apply to aggregates may not apply to individuals. They recommend further research to study individuals for the effect of vitamin D from sunlight, diet and supplements on the risk of breast cancer.

This is the fourth environmental paper from this research team to show a strong association between vitamin D and cancer using global incidence data (GLOBOCAN). The first paper, which illuminated a similar pattern for kidney cancer, was published Sept. 15, 2006, in the International Journal of Cancer. The second, on ovarian cancer, was published Oct. 31, 2006, in the American Journal of Preventive Medicine. The third, on endometrial cancer, was published Sept. 16, 2007, in Preventive Medicine.

Authors on the new study are Cedric F. Garland, Dr. P.H., Frank C. Garland, Ph.D.; Edward D. Gorham, Ph.D.; William B. Grant, Ph.D.; and Sharif B. Mohr, M.P.H. Authors' institutional affiliations are UCSD Department of Family and Preventive Medicine and Moores UCSD Cancer Center (Mohr, C. Garland, Gorham and F. Garland), and the Sunlight, Nutrition and Health Research Center, San Francisco (Grant).


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sharif B. Mohr MPH, Cedric F. Garland Dr. PH, Edward D. Gorham MPH, PhD, William B. Grant PhD, Frank C. Garland PhD (2008) Relationship between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 Countries The Breast Journal 14 (3) , 255–260 doi:10.1111/j.1524-4741.2008.00571.x [link]

Cite This Page:

University of California - San Diego. "Link Between Vitamin D Status And Breast Cancer Illuminated." ScienceDaily. ScienceDaily, 16 May 2008. <www.sciencedaily.com/releases/2008/05/080515174000.htm>.
University of California - San Diego. (2008, May 16). Link Between Vitamin D Status And Breast Cancer Illuminated. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2008/05/080515174000.htm
University of California - San Diego. "Link Between Vitamin D Status And Breast Cancer Illuminated." ScienceDaily. www.sciencedaily.com/releases/2008/05/080515174000.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins