Featured Research

from universities, journals, and other organizations

Tracking The Effects Of Addictive Drugs On Brain

Date:
May 18, 2008
Source:
The Mount Sinai Hospital / Mount Sinai School of Medicine
Summary:
Researchers may have unlocked the key to better understanding the effect addictive drugs have on the human brain. Researchers discovered that a drug that works through the cannabinoid 1 receptor recognizing the active ingredient of marijuana activates many different transcription factors, triggering the differentiation of neurons, causing permanent changes in a person's brain.

Mount Sinai researchers may have unlocked the key to better understanding the effect addictive drugs have on the human brain.

"The research findings give us a new window into the brain, helping us to better understand the role addictive drugs have on the inner workings of brain cells ," said Ravi Iyengar Ph.D., study author and Dorothy H. and Lewis Rosenstiel Professor and Chair, Department of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine.

"This type of research provides may clues for targets within brain cells against which drugs that block addiction may be targeted."

Mount Sinai researchers looked at the systems biology approach in order to study molecular networks underlying addiction.

The findings start to unravel the complex interactions within brain cells, which are involved in processing signals from receptors in the brain that recognize the addictive drugs.

Researchers discovered that a drug that works through the cannabinoid 1 receptor recognizing the active ingredient of marijuana activates many different transcription factors, triggering the differentiation of neurons, causing permanent changes in a person's brain.

Another result of study was the discovery of a new role of the breast cancer gene BRCA 1 in neuronal differentiation and the effects of addictive drugs upon them.



Story Source:

The above story is based on materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kenneth D. Bromberg, Avi Ma'ayan, Susana R. Neves, Ravi Iyengar. Design Logic of a Cannabinoid Receptor Signaling Network that Triggers Neurite Outgrowth. Science 16 May 2008: Vol. 320. no. 5878, pp. 903 - 909. DOI: 10.1126/science.1152662 [link]

Cite This Page:

The Mount Sinai Hospital / Mount Sinai School of Medicine. "Tracking The Effects Of Addictive Drugs On Brain." ScienceDaily. ScienceDaily, 18 May 2008. <www.sciencedaily.com/releases/2008/05/080516094438.htm>.
The Mount Sinai Hospital / Mount Sinai School of Medicine. (2008, May 18). Tracking The Effects Of Addictive Drugs On Brain. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2008/05/080516094438.htm
The Mount Sinai Hospital / Mount Sinai School of Medicine. "Tracking The Effects Of Addictive Drugs On Brain." ScienceDaily. www.sciencedaily.com/releases/2008/05/080516094438.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins