Featured Research

from universities, journals, and other organizations

Turn Off Gene Regulators To Tune In To Development

Date:
May 21, 2008
Source:
Journal of Clinical Investigation
Summary:
For a fertilized egg to develop into an embryo a mass of identical cells must be directed to become a large number of distinct cell types with different functions and then these cells must be organized into functional organs and tissues. The proteins that direct these crucial events control the expression of an enormous number of genes and are known as transcription factors.

For a fertilized egg to develop into an embryo a mass of identical cells must be directed to become a large number of distinct cell types with different functions and then these cells must be organized into functional organs and tissues.

Related Articles


The proteins that direct these crucial events control the expression of an enormous number of genes and are known as transcription factors. Expression of transcription factors is itself tightly controlled and usually only occurs while the developmental step they regulate is taking place. Although many studies have established the importance of turning on a transcription factor at the correct time, few studies have investigated whether it is important when the transcription factor is turned off.

However, new data, generated by Jonathan Epstein and colleagues, at the University of Pennsylvania, Philadelphia, have now indicated that inactivation of transcription factors is important for normal mouse development.

In the study, mice were engineered to express the transcription factor Pax3, which controls the development of cells known as neural crest cells into many different cell types (including some bone cells, some muscle cells, and some nerves), beyond the time it is normally shut off. Defects in craniofacial bone structures derived from neural crest cells were observed in these mice and they died within two days of birth due to cleft or shortened palates.

Detailed analysis revealed that Pax3 prevented neural crest cells from responding to a factor that induces bone development (BMP-2), because it directly upregulated expression of the gene containing the information for making the protein Sostdc1, a soluble inhibitor of BMP signaling. The authors therefore conclude one function of Pax3 is to maintain neural crest cells in an undifferentiated state by preventing them from responding to factors that induce bone development.

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. Journal of Clinical Investigation. May 15, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Turn Off Gene Regulators To Tune In To Development." ScienceDaily. ScienceDaily, 21 May 2008. <www.sciencedaily.com/releases/2008/05/080516163315.htm>.
Journal of Clinical Investigation. (2008, May 21). Turn Off Gene Regulators To Tune In To Development. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2008/05/080516163315.htm
Journal of Clinical Investigation. "Turn Off Gene Regulators To Tune In To Development." ScienceDaily. www.sciencedaily.com/releases/2008/05/080516163315.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins