Featured Research

from universities, journals, and other organizations

Targeting A Pathological Area Using MRI

Date:
May 22, 2008
Source:
CNRS
Summary:
Magnetic resonance imaging (MRI) has become a common tool in clinical diagnosis due to the use of contrast agents, which are like colorants, enabling the contrast between healthy tissue and diseased tissue to be increased. However, the agents currently used clinically do not allow the identification of particular pathologies or of the affected area of the body. The recent work has brought new hope to this field.

In the diagram, the light bulb represents the contrast agent. If the enzyme is present, the contrast agent is activated and "lights up", making it detectable in an MRI image.
Credit: Copyright ICSN

Magnetic resonance imaging (MRI) has become a common tool in clinical diagnosis due to the use of contrast agents, which are like colorants, enabling the contrast between healthy tissue and diseased tissue to be increased. However, the agents currently used clinically do not allow the identification of particular pathologies or of the affected area of the body. The recent work of two CNRS teams from Orleans and Gif-sur-Yvette (Orleans' Centre de biophysique moléculaire and the Institut de chimie des substances naturelles in Gif-sur-Yvette) has brought hope in this field.

CNRS researchers have demonstrated that by using a new class of contrast agents sensitive to enzymes, it is possible to locate the affected part of the body. The molecules act as molecular switches – when they encounter a specific enzyme, this sets off a cascade reaction, leading to the activation of the contrast agent which then becomes detectable in an MRI image. The systems have two positions – they are “off” in the absence of the enzyme, and “on” if it is present. Therefore, an image is only received when the contrast agents are activated.

The reactions caused by certain enzymes may be an indication of the state of the cells, and be interpreted as the signature of a given pathology. In the future, detection of enzymes thanks to these contrast agents should enable doctors to diagnose a disease  with a simple MRI examination. Furthermore, the system can be modulated and is potentially applicable to a great variety of enzymes, and, therefore, pathologies.

Understanding the mechanism of these new molecules for medical imaging constitutes a major advance in visualizing molecular processes in vivo, as well as in detecting pathologies.


Story Source:

The above story is based on materials provided by CNRS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes. Thomas Chauvin, Philippe Durand, Michèle Bernier, Hervé Meudal, Bich-Thuy Doan, Fanny Noury, Bernard Badet, Jean-Claude Beloeil, Eva Jakab Toth, Angewandte Chemie International Edition, Online. doi:10.1002/anie.200800809 [link]

Cite This Page:

CNRS. "Targeting A Pathological Area Using MRI." ScienceDaily. ScienceDaily, 22 May 2008. <www.sciencedaily.com/releases/2008/05/080519154844.htm>.
CNRS. (2008, May 22). Targeting A Pathological Area Using MRI. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/05/080519154844.htm
CNRS. "Targeting A Pathological Area Using MRI." ScienceDaily. www.sciencedaily.com/releases/2008/05/080519154844.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins