Featured Research

from universities, journals, and other organizations

Targeting A Pathological Area Using MRI

Date:
May 22, 2008
Source:
CNRS
Summary:
Magnetic resonance imaging (MRI) has become a common tool in clinical diagnosis due to the use of contrast agents, which are like colorants, enabling the contrast between healthy tissue and diseased tissue to be increased. However, the agents currently used clinically do not allow the identification of particular pathologies or of the affected area of the body. The recent work has brought new hope to this field.

In the diagram, the light bulb represents the contrast agent. If the enzyme is present, the contrast agent is activated and "lights up", making it detectable in an MRI image.
Credit: Copyright ICSN

Magnetic resonance imaging (MRI) has become a common tool in clinical diagnosis due to the use of contrast agents, which are like colorants, enabling the contrast between healthy tissue and diseased tissue to be increased. However, the agents currently used clinically do not allow the identification of particular pathologies or of the affected area of the body. The recent work of two CNRS teams from Orleans and Gif-sur-Yvette (Orleans' Centre de biophysique moléculaire and the Institut de chimie des substances naturelles in Gif-sur-Yvette) has brought hope in this field.

CNRS researchers have demonstrated that by using a new class of contrast agents sensitive to enzymes, it is possible to locate the affected part of the body. The molecules act as molecular switches – when they encounter a specific enzyme, this sets off a cascade reaction, leading to the activation of the contrast agent which then becomes detectable in an MRI image. The systems have two positions – they are “off” in the absence of the enzyme, and “on” if it is present. Therefore, an image is only received when the contrast agents are activated.

The reactions caused by certain enzymes may be an indication of the state of the cells, and be interpreted as the signature of a given pathology. In the future, detection of enzymes thanks to these contrast agents should enable doctors to diagnose a disease  with a simple MRI examination. Furthermore, the system can be modulated and is potentially applicable to a great variety of enzymes, and, therefore, pathologies.

Understanding the mechanism of these new molecules for medical imaging constitutes a major advance in visualizing molecular processes in vivo, as well as in detecting pathologies.

 


Story Source:

The above story is based on materials provided by CNRS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes. Thomas Chauvin, Philippe Durand, Michèle Bernier, Hervé Meudal, Bich-Thuy Doan, Fanny Noury, Bernard Badet, Jean-Claude Beloeil, Eva Jakab Toth, Angewandte Chemie International Edition, Online. doi:10.1002/anie.200800809 [link]

Cite This Page:

CNRS. "Targeting A Pathological Area Using MRI." ScienceDaily. ScienceDaily, 22 May 2008. <www.sciencedaily.com/releases/2008/05/080519154844.htm>.
CNRS. (2008, May 22). Targeting A Pathological Area Using MRI. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2008/05/080519154844.htm
CNRS. "Targeting A Pathological Area Using MRI." ScienceDaily. www.sciencedaily.com/releases/2008/05/080519154844.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins