Featured Research

from universities, journals, and other organizations

Insights Into Lung Disease And Lung Function In Young Adults

Date:
May 24, 2008
Source:
American Thoracic Society
Summary:
Two new studies provide insights into lung disease and lung function in young adults. One links low levels of a protein called adiponectin in fat cells to an increase in asthma risk in young women. A second finds that high levels of a protein called ICAM-1 is associated with lower lung function.

Two studies being presented at the American Thoracic Society's 2008 International Conference in Toronto on May 21 provide insights into lung disease and lung function in young adults. One links low levels of a protein called adiponectin in fat cells to an increase in asthma risk in young women. A second finds that high levels of a protein called ICAM-1 is associated with lower lung function.

Related Articles


The data from both studies comes from the National Heart, Lung, and Blood Institute's CARDIA (Coronary Artery Risk Development in Young Adults) observational cohort, which recently completed 20 years of health assessment in more than 5,000 young adults. Participants were healthy 18 to 30 year-olds when the study began in 1985 and 1986. The goal of the research has been to look for risk factors for cardiovascular and lung disease as participants age.

Low Levels of Protein in Fat Cells May Increase Asthma Risk in Women

Low levels of adiponectin, a protein produced by fat cells, are associated with an increased risk of asthma in women, according to one CARDIA study.

Although adiponectin is produced in fat cells, obesity may trigger an inflammatory response to it, and its production is diminished in obese people. Levels of adiponectin increase with weight loss. To determine the effect of adiponectin on asthma, researchers divided 2,890 men and women from the CARDIA study into thirds according to the amount of adiponectin their fat cells produced.

Women with the lowest amount of adiponectin, who also tended to be more obese, had almost double the risk of developing asthma, compared to women who had the most adiponectin in their blood. This was true regardless of the women's weight. The effect was most evident in the premenopausal women, who represented 90 percent of the 1,603 women included in the study. The researchers did not see a similar relationship between adiponectin levels and asthma in men.

"Our finding that adiponectin may have a protective effect on asthma in women may open up doors to new ways of treating asthma," said lead researcher Akshay Sood, M.D., M.P.H., associate professor in the Division of Pulmonary and Critical Care Medicine at the University of New Mexico Health Sciences Center School of Medicine in Albuquerque. "The findings have particular relevance for obese women, since they are more likely to have low blood adiponectin concentrations."

While human studies of adiponectin and asthma are still in the early stages, studies of mice indicate that this protein plays a role in airway inflammation and airway hyperreactivity, or "twitchiness," both of which are factors in asthma.

"Because of the increase in asthma prevalence, as well as obesity, there should be a lot of interest in continuing to study the effect of products of fat cells on asthma," Dr. Sood said.

The talk is entitled: "Adipokine-Asthma association: Does Lung "Talk" to Adipose Tissue?"

High Protein Levels May Signal Lower Lung Function

A second study based on CARDIA data finds that higher levels of proteins called ICAM-1 (intracellular adhesion molecule) are associated with lower lung function.

ICAM-1 exists in the cells called endothelial cells that line the arteries, and helps initiate the immune system's inflammatory response to "invaders" such as cholesterol deposits.

"Circulating ICAM-1 is a measure of dysfunction of the endothelial cells, which are the intimal lining of arteries and are in capillaries," said study co-author David Jacobs, Ph.D., Mayo Professor of Public Health at the University of Minnesota in Minneapolis. "We've known that people with lower lung function have more cardiovascular disease and cardiovascular deaths than those with better lung function, and that these two things are somehow related, but the relationship between the lungs and blood vessels has been puzzling. For instance, air pollution, although it is breathed in through the lungs, has been shown to cause more heart disease than lung disease."

The study included 2,455 participants from CARDIA. Their levels of ICAM-1 during year 15 of the study were compared with their lung function in year 20. "We found a fairly substantial decline in lung function in people with the highest levels of ICAM, compared with people with lower levels, regardless of their weight," Dr. Jacobs said. "It suggests that lung function and endothelial health are related in some way. I think of endothelial dysfunction, oxidative stress and inflammation as evil triplets, feeding on each other."

More research is needed to better understand the relationship between the lungs and blood vessels, in order to help preserve better lung function throughout a person's life, he said.

The talk is etitled: "Association of Circulating Adhesion Molecules with Lung Function: Results from the CARDIA Study"


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Insights Into Lung Disease And Lung Function In Young Adults." ScienceDaily. ScienceDaily, 24 May 2008. <www.sciencedaily.com/releases/2008/05/080521081921.htm>.
American Thoracic Society. (2008, May 24). Insights Into Lung Disease And Lung Function In Young Adults. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2008/05/080521081921.htm
American Thoracic Society. "Insights Into Lung Disease And Lung Function In Young Adults." ScienceDaily. www.sciencedaily.com/releases/2008/05/080521081921.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins