Featured Research

from universities, journals, and other organizations

New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers

Date:
May 27, 2008
Source:
University Hospital Heidelberg
Summary:
Researchers have discovered a new strategy for an immunization against certain forms of cancer. They have determined that immune cells react strongly to the modified proteins in tumor cells in which a DNA repair defect has occurred. It is estimated that this repair defect is present in some 15 percent of all tumors.

Immunization against “false” proteins could sensitize the immune system against tumour cells.

Researchers in Heidelberg have discovered a new strategy for an immunization against certain forms of cancer. They have determined that immune cells react strongly to the modified proteins in tumor cells in which a DNA repair defect has occurred. It is estimated that this repair defect is present in some 15 percent of all tumours.

The researchers, led by Professor Dr. Magnus von Knebel Doeberitz, Medical Director of the Department of Applied Tumor Biology at the Heidelberg University Hospital, studied the most frequent form of hereditary colon cancer, the HNPCC syndrome (Hereditary Non-Polyposis Colorectal Cancer Syndrome).

In Germany, colon cancer, with about 65,000 new cases per year, is the third most common form of cancer. In about 15 percent of these tumors, there is a defect in certain repair mechanisms of the DNA that leads mainly to changes in the so-called microsatellites. As the researchers in Heidelberg have now discovered, these changes in microsatellites cause the tumour cells to begin forming foreign proteins, which can be recognized and attacked by the immune system.

But why are tumours formed despite the immune reaction? “There are two reasons for this,” says Professor von Knebel Doeberitz. “The immune system often reacts too slowly – and some tumor cells are able to hide because they lose the ability to express the foreign proteins on their surface.”

The results of the Heidelberg research team suggest that the growth of tumous with microsatellite changes can be prevented if the immune system can be activated against the foreign proteins in time. The researchers’ next goal is thus to develop a vaccine against these types of cancer from the new foreign proteins that are created from mutations. If the immune system is sensitized against the “enemy” by immunization, it could react rapidly and strongly when cancer cells or their early stages appear.

The new immunization strategy could be effective against 10 to 15 percent of all cancers. The new results are especially significant for patients who suffer from the most frequent form of hereditary colon cancer, the HNPCC syndrome (Hereditary Non-Polyposis Colorectal Cancer Syndrome). Almost all tumours of this form are affected by the changes in microsatellites.

The research was conducted in co-operation with the German Cancer Research Center and the European Molecular Biology Laboratory (EMBL) and was funded with € 380,000 by the Deutsche Krebshilfe (German Cancer Aid).


Story Source:

The above story is based on materials provided by University Hospital Heidelberg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yvette Schwitalle, Matthias Kloor, Susanne Eiermann, Michael Linnebacher, Peter Kienle, Hanns Peter Knaebel, Mirjam Tariverdian, Axel Benner, Magnus von Knebel Doeberitz, Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers, Gastroenterology 2008, 134, 988-997.

Cite This Page:

University Hospital Heidelberg. "New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers." ScienceDaily. ScienceDaily, 27 May 2008. <www.sciencedaily.com/releases/2008/05/080527091916.htm>.
University Hospital Heidelberg. (2008, May 27). New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2008/05/080527091916.htm
University Hospital Heidelberg. "New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers." ScienceDaily. www.sciencedaily.com/releases/2008/05/080527091916.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins