Featured Research

from universities, journals, and other organizations

New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers

Date:
May 27, 2008
Source:
University Hospital Heidelberg
Summary:
Researchers have discovered a new strategy for an immunization against certain forms of cancer. They have determined that immune cells react strongly to the modified proteins in tumor cells in which a DNA repair defect has occurred. It is estimated that this repair defect is present in some 15 percent of all tumors.

Immunization against “false” proteins could sensitize the immune system against tumour cells.

Related Articles


Researchers in Heidelberg have discovered a new strategy for an immunization against certain forms of cancer. They have determined that immune cells react strongly to the modified proteins in tumor cells in which a DNA repair defect has occurred. It is estimated that this repair defect is present in some 15 percent of all tumours.

The researchers, led by Professor Dr. Magnus von Knebel Doeberitz, Medical Director of the Department of Applied Tumor Biology at the Heidelberg University Hospital, studied the most frequent form of hereditary colon cancer, the HNPCC syndrome (Hereditary Non-Polyposis Colorectal Cancer Syndrome).

In Germany, colon cancer, with about 65,000 new cases per year, is the third most common form of cancer. In about 15 percent of these tumors, there is a defect in certain repair mechanisms of the DNA that leads mainly to changes in the so-called microsatellites. As the researchers in Heidelberg have now discovered, these changes in microsatellites cause the tumour cells to begin forming foreign proteins, which can be recognized and attacked by the immune system.

But why are tumours formed despite the immune reaction? “There are two reasons for this,” says Professor von Knebel Doeberitz. “The immune system often reacts too slowly – and some tumor cells are able to hide because they lose the ability to express the foreign proteins on their surface.”

The results of the Heidelberg research team suggest that the growth of tumous with microsatellite changes can be prevented if the immune system can be activated against the foreign proteins in time. The researchers’ next goal is thus to develop a vaccine against these types of cancer from the new foreign proteins that are created from mutations. If the immune system is sensitized against the “enemy” by immunization, it could react rapidly and strongly when cancer cells or their early stages appear.

The new immunization strategy could be effective against 10 to 15 percent of all cancers. The new results are especially significant for patients who suffer from the most frequent form of hereditary colon cancer, the HNPCC syndrome (Hereditary Non-Polyposis Colorectal Cancer Syndrome). Almost all tumours of this form are affected by the changes in microsatellites.

The research was conducted in co-operation with the German Cancer Research Center and the European Molecular Biology Laboratory (EMBL) and was funded with € 380,000 by the Deutsche Krebshilfe (German Cancer Aid).


Story Source:

The above story is based on materials provided by University Hospital Heidelberg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yvette Schwitalle, Matthias Kloor, Susanne Eiermann, Michael Linnebacher, Peter Kienle, Hanns Peter Knaebel, Mirjam Tariverdian, Axel Benner, Magnus von Knebel Doeberitz, Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers, Gastroenterology 2008, 134, 988-997.

Cite This Page:

University Hospital Heidelberg. "New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers." ScienceDaily. ScienceDaily, 27 May 2008. <www.sciencedaily.com/releases/2008/05/080527091916.htm>.
University Hospital Heidelberg. (2008, May 27). New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2008/05/080527091916.htm
University Hospital Heidelberg. "New Immunization Strategy Could Be Effective Against 10 To 15 Percent Of All Cancers." ScienceDaily. www.sciencedaily.com/releases/2008/05/080527091916.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Calling All Men: Here's Your Chance to Experience Labor Pains

Calling All Men: Here's Your Chance to Experience Labor Pains

Reuters - Light News Video Online (Nov. 20, 2014) Chinese hospital offers men a chance to experience the pain of child birth via electric shocks. Sharon Reich reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins