Featured Research

from universities, journals, and other organizations

Magnetic Nanoparticles: Suitable For Cancer Therapy?

Date:
May 31, 2008
Source:
Physikalisch-Technische Bundesanstalt
Summary:
A new measuring procedure can help to investigate in some detail the behavior of magnetic nanoparticles which are used for cancer therapy.

Atomic force microscopic image of magnetic nanoparticles of cobalt ferrite. The diagram shows the size distribution.
Credit: Image courtesy of Physikalisch-Technische Bundesanstalt

A measuring procedure developed in the Physikalisch-Technische Bundesanstalt (PTB) can help to investigate in some detail the behaviour of magnetic nanoparticles which are used for cancer therapy.

Magnetic nanoparticles (with a size of some few to several hundred nanometres) are a new, promising means of fighting cancer. The particles serve as a carrier for drugs: "loaded" with the drugs, the nanoparticles are released into the blood stream, where they move until they come under the influence of a targeting magnetic field which holds them on to the tumour - until the drug has released its active agent. Besides this pharmaceutical effect, also a physical action can be applied: an electromagnetic a.c. field heats up the accumulated particles so much that they destroy the tumour. Both therapeutic concepts have the advantage of largely avoiding undesired side effects on the healthy tissue.

These procedures have already been successfully been applied in the animal model and have, in part, already been tested on patients. Here it is important to know before application whether the particles tend to aggregate and thus might occlude blood vessels. Information about this can be gained by magnetorelaxometry developed at the PTB. In this procedure, the particles are shortly magnetised by a strong magnetic field in order to measure their relaxation after the switch-off of the field by means of superconducting quantum interferometers, so-called "SQUIDs".

Conclusions on their aggregation behaviour in these media can be drawn from measurements of suspensions of nanoparticles in the serum or in whole blood. As an example, it could be shown in this way that certain nanoparticles in the blood serum form clusters with a diameter of up to 200 nm - a clear indication of aggregation, so that these nanoparticles do not appear to be suitable for therapy

At present, the high technical effort connected with the use of helium-cooled magnetic field sensors is still standing in the way of using this method routinely in practice. In a joint project with Braunschweig Technical University supported by the Ministry of Education and Research (BMBF), the procedure is currently being transferred to a simpler technology based on fluxgate magnetometers.

The results of the first orders from customers have served, for example, to optimise the paint drying process in the automobile industry, the thermal design of furnaces as well as the monitoring of glass forming processes.

Another measuring facility is currently being set up in the PTB which will allow emissivity measurements to be performed under vacuum conditions in an extended temperature and wavelength range - in particular for space applications.


Story Source:

The above story is based on materials provided by Physikalisch-Technische Bundesanstalt. Note: Materials may be edited for content and length.


Cite This Page:

Physikalisch-Technische Bundesanstalt. "Magnetic Nanoparticles: Suitable For Cancer Therapy?." ScienceDaily. ScienceDaily, 31 May 2008. <www.sciencedaily.com/releases/2008/05/080528095649.htm>.
Physikalisch-Technische Bundesanstalt. (2008, May 31). Magnetic Nanoparticles: Suitable For Cancer Therapy?. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2008/05/080528095649.htm
Physikalisch-Technische Bundesanstalt. "Magnetic Nanoparticles: Suitable For Cancer Therapy?." ScienceDaily. www.sciencedaily.com/releases/2008/05/080528095649.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins