Featured Research

from universities, journals, and other organizations

Link Between Inflammation, Cancer Confirmed

Date:
June 3, 2008
Source:
Massachusetts Institute of Technology
Summary:
Chronic inflammation of the intestine or stomach can damage DNA, increasing the risk of cancer, MIT scientists have confirmed. Chronic inflammation accelerated tumor formation in mice lacking the ability to repair DNA damage.

Chronic inflammation of the intestine or stomach can damage DNA, increasing the risk of cancer, MIT scientists have confirmed.

Related Articles


The researchers published evidence of the long-suspected link in the Journal of Clinical Investigation. In two studies, the researchers found that chronic inflammation accelerated tumor formation in mice lacking the ability to repair DNA damage.

"It's something that was expected but it was never formally proven," said Lisiane Meira, research scientist in MIT's Center for Environmental Health Sciences (CEHS) and lead author of the paper.

The results of this work suggest that people with decreased ability to repair DNA damage might be more susceptible to developing cancer associated with chronic inflammation such as ulcerative colitis, Meira said.

Inflammation caused by infectious agents such as Helicobacter pylori and Hepatitis C is known to increase the risk of stomach and liver cancers, respectively. Researchers have long known that inflammation produces cytokines (immune response chemicals that encourage cell proliferation and suppress cell death), which can lead to cancer.

In addition, it was suspected that another effect of the inflammation pathway could also induce cancer. During the inflammatory response to infection, immune cells such as macrophages and neutrophils release reactive oxygen and nitrogen species that can damage DNA.

Under normal circumstances, the DNA damage induced during an inflammatory response is repaired by DNA repair systems. But, if the DNA repair system is not functioning properly, that damage can induce mutations that can lead to cancer, according to the new study.

Every individual has variations in the effectiveness of their DNA repair systems, which could help doctors figure out which patients are most susceptible to inflammation-induced cancers.

"That variation could influence the susceptibility of individuals and how they are going to respond to a chronic inflammation response," said Leona Samson, senior author of the study and director of the CEHS.

In the JCI study, the researchers induced colon inflammation in the mice by treating them with a chemical compound that creates a condition similar to human colitis. "Lo and behold, the DNA repair deficient mice were more susceptible" to cancer, said Meira.

To show that this is a general phenomenon, the team did a second study, in collaboration with another CEHS member, James Fox, director of the Division of Comparative Medicine at MIT, and one of his students, Chung-Wei Lee. They showed that mice infected with H. pylori, who also lacked the proper DNA repair mechanisms, were more susceptible to pre-cancerous lesions in the stomach.

This study is related to another recent paper published by Fox, which found that treating H. pylori infection early with antibiotics can prevent cancer development. The new study suggests that if H. pylori goes untreated, patients with poorly functioning DNA repair mechanisms would have a greater risk of developing cancer.

Other CEHS faculty involved in the JCI report were Peter Dedon and David Schauer. The research was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Massachusetts Institute of Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Meira et al. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. Journal of Clinical Investigation, 2008; DOI: 10.1172/JCI35073

Cite This Page:

Massachusetts Institute of Technology. "Link Between Inflammation, Cancer Confirmed." ScienceDaily. ScienceDaily, 3 June 2008. <www.sciencedaily.com/releases/2008/06/080602214138.htm>.
Massachusetts Institute of Technology. (2008, June 3). Link Between Inflammation, Cancer Confirmed. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2008/06/080602214138.htm
Massachusetts Institute of Technology. "Link Between Inflammation, Cancer Confirmed." ScienceDaily. www.sciencedaily.com/releases/2008/06/080602214138.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins