Featured Research

from universities, journals, and other organizations

Sour Comes After A Lemon Has Gone

Date:
June 9, 2008
Source:
National Institute for Physiological Sciences
Summary:
Scientists found that a sour taste receptor, PKD1L3-PKD2L1 channel complex, could be activated by acid stimulus but opened gate only after the removal of acid stimulus. They call this new type of response as "off-response" of sour taste receptor.

The research group led by Professor Makoto Tominaga and Research Assistant Professor Hitoshi Inada (National Institute for Physiological Sciences, Okazaki, Japan) found that a sour taste receptor, PKD1L3-PKD2L1 channel complex, could be activated by acid stimulus but opened gate only after the removal of acid stimulus. They call this new type of response as "off-response" of sour taste receptor.

They investigated the PKD1L3-PKD2L1 channel activity stimulated by acid stimulus with calcium imaging method and electrophysiology. The cultured cells expressing PKD1L3-PKD2L1 channels showed a significant increase in intracellular Ca2+ not during the acid stimulation but only after the acid stimulus was washed out. The off-response property was also confirmed by whole cell patch-clamp configuration.

Prof Tominaga and Dr. Inada said "The PKD1L3-PKD2L1 channels exist on the taste bud in the side and the inner part of tongue, where the salivary glands are close. Acidic things such as spoiled foods and harmful solutions are supposed to be dangerous to human body so that they should be quickly removed by saliva. The off-response of PKD1L3-PKD2L1 channels, we found here, helps human to keep sour taste sensation even after acid stimulus has been washed out."

They reports their finding in an international journal, EMBO reports, on June 6, 2008.


Story Source:

The above story is based on materials provided by National Institute for Physiological Sciences. Note: Materials may be edited for content and length.


Cite This Page:

National Institute for Physiological Sciences. "Sour Comes After A Lemon Has Gone." ScienceDaily. ScienceDaily, 9 June 2008. <www.sciencedaily.com/releases/2008/06/080606084117.htm>.
National Institute for Physiological Sciences. (2008, June 9). Sour Comes After A Lemon Has Gone. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2008/06/080606084117.htm
National Institute for Physiological Sciences. "Sour Comes After A Lemon Has Gone." ScienceDaily. www.sciencedaily.com/releases/2008/06/080606084117.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins