Featured Research

from universities, journals, and other organizations

RNA Induction Of An Epigenetic Hereditary Pathology

Date:
June 9, 2008
Source:
Cell Press
Summary:
A new study shows that microinjection of RNA molecules into mouse embryos induces a hereditary form of cardiac hypertrophy that is similar to human hypertrophic cardiomyopathy. The research may provide a paradigm for clinical cases of familial diseases not readily explained by DNA mutations.

A new study shows that microinjection of RNA molecules into mouse embryos induces a hereditary form of cardiac hypertrophy that is similar to human hypertrophic cardiomyopathy (HCM). The research, published by Cell Press in the June issue of the journal Developmental Cell, may provide a paradigm for clinical cases of familial diseases not readily explained by DNA mutations.

Related Articles


Dr. Minoo Rassoulzadegan from the University of Nice and her colleagues had previously shown that RNA, a molecule that is similar to DNA and important for the process of protein synthesis, can play an unexpected role in passing characteristics on to future generations, even in the absence of DNA mutations affecting those characteristics. This phenomenon is known as hereditary epigenetic determination, or paramutation.

The researchers sought to expand on this earlier work by examining the relevance of paramutation to pathophysiology and disease. They focused on HCM, an important often hereditary heart disease characterized by enlargement of cardiac muscle cells. "There is no clear molecular link between mutations associated with hereditary cardiomyopathies, inheritance of the disease and the abnormal growth of cardiac muscle cells, leading to the suspicion that other, still unknown factors are involved," offers Dr. Rassoulzadegan.

Dr. Rassoulzadegan's group used their method to show that injecting microRNA-1, a known regulator of cardiac development, into one-cell mouse embryos resulted in mice with substantially enlarged hearts similar to HCM. The injected RNA initiated epigenetic changes in targets such as Cdk9, a gene that regulates cardiac growth. Remarkably, these changes were then inherited both paternally and maternally for three generations. The authors attribute this phenomenon to the transmission of the excess microRNA via sperm.

The authors conclude that hereditary human cardiac problems that do not seem linked to DNA mutations may be caused instead by aberrant RNAs. "These results highlight the diversity of RNA-mediated epigenetic effects. They extend the concept of a mode of variation and heredity, distinct from and complementary to principles of Mendelian genetics, an observation that is potentially significant for both fundamental biology and pathology," says Dr. Rassoulzadegan.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "RNA Induction Of An Epigenetic Hereditary Pathology." ScienceDaily. ScienceDaily, 9 June 2008. <www.sciencedaily.com/releases/2008/06/080609124605.htm>.
Cell Press. (2008, June 9). RNA Induction Of An Epigenetic Hereditary Pathology. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2008/06/080609124605.htm
Cell Press. "RNA Induction Of An Epigenetic Hereditary Pathology." ScienceDaily. www.sciencedaily.com/releases/2008/06/080609124605.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins