Featured Research

from universities, journals, and other organizations

RNA Induction Of An Epigenetic Hereditary Pathology

Date:
June 9, 2008
Source:
Cell Press
Summary:
A new study shows that microinjection of RNA molecules into mouse embryos induces a hereditary form of cardiac hypertrophy that is similar to human hypertrophic cardiomyopathy. The research may provide a paradigm for clinical cases of familial diseases not readily explained by DNA mutations.

A new study shows that microinjection of RNA molecules into mouse embryos induces a hereditary form of cardiac hypertrophy that is similar to human hypertrophic cardiomyopathy (HCM). The research, published by Cell Press in the June issue of the journal Developmental Cell, may provide a paradigm for clinical cases of familial diseases not readily explained by DNA mutations.

Dr. Minoo Rassoulzadegan from the University of Nice and her colleagues had previously shown that RNA, a molecule that is similar to DNA and important for the process of protein synthesis, can play an unexpected role in passing characteristics on to future generations, even in the absence of DNA mutations affecting those characteristics. This phenomenon is known as hereditary epigenetic determination, or paramutation.

The researchers sought to expand on this earlier work by examining the relevance of paramutation to pathophysiology and disease. They focused on HCM, an important often hereditary heart disease characterized by enlargement of cardiac muscle cells. "There is no clear molecular link between mutations associated with hereditary cardiomyopathies, inheritance of the disease and the abnormal growth of cardiac muscle cells, leading to the suspicion that other, still unknown factors are involved," offers Dr. Rassoulzadegan.

Dr. Rassoulzadegan's group used their method to show that injecting microRNA-1, a known regulator of cardiac development, into one-cell mouse embryos resulted in mice with substantially enlarged hearts similar to HCM. The injected RNA initiated epigenetic changes in targets such as Cdk9, a gene that regulates cardiac growth. Remarkably, these changes were then inherited both paternally and maternally for three generations. The authors attribute this phenomenon to the transmission of the excess microRNA via sperm.

The authors conclude that hereditary human cardiac problems that do not seem linked to DNA mutations may be caused instead by aberrant RNAs. "These results highlight the diversity of RNA-mediated epigenetic effects. They extend the concept of a mode of variation and heredity, distinct from and complementary to principles of Mendelian genetics, an observation that is potentially significant for both fundamental biology and pathology," says Dr. Rassoulzadegan.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "RNA Induction Of An Epigenetic Hereditary Pathology." ScienceDaily. ScienceDaily, 9 June 2008. <www.sciencedaily.com/releases/2008/06/080609124605.htm>.
Cell Press. (2008, June 9). RNA Induction Of An Epigenetic Hereditary Pathology. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/06/080609124605.htm
Cell Press. "RNA Induction Of An Epigenetic Hereditary Pathology." ScienceDaily. www.sciencedaily.com/releases/2008/06/080609124605.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins