Featured Research

from universities, journals, and other organizations

Outing The Outliers: Strategy Matches Oncogene With Subtype Of Prostate Cancer

Date:
June 11, 2008
Source:
Cell Press
Summary:
A new study reveals a previously unidentified candidate oncogene that appears to play a significant role in a subset of prostate cancers. The research describes a new strategy that can be used to find "outlier" genes in cancer subtypes that are not well understood.

A new study reveals a previously unidentified candidate oncogene that appears to play a significant role in a subset of prostate cancers. The research, published by Cell Press in the June issue of the journal Cancer Cell, describes a new strategy that can be used to find "outlier" genes in cancer subtypes that are not well understood.

"We know that ETS gene fusions occur in 40%-80% of prostate-specific antigen (PSA)-screened prostate cancers, leaving 20%-60% of prostate cancers in which the key genetic aberration is unknown. Further, we have shown that ETS-positive and --negative cancers have distinct transcriptional signatures, suggesting that unique oncogenes and downstream targets play a role in fusion-negative cancers," explains lead author, Dr. Arul M. Chinnaiyan from the University of Michigan Medical School.

Dr. Chinnaiyan and colleagues sought out oncogenes that drive ETS-negative prostate cancers using a refined version of a newly developed approach called, Cancer Outlier Profile Analysis (COPA), that identifies outlier oncogenes in a specific subset of cancer cases. Using this methodology to examine data from seven prostate cancer profiling studies, they identified SPINK1 (serine peptidase inhibitor, Kazal type 1) as being overexpressed in prostate cancer when compared to benign prostate cells and displaying mutually exclusive overexpression with ETS family members.

SPINK1 outlier expression could be detected noninvasively in urine and SPINK1 outlier expression was shown to be an effective independent predictor of prostate cancer recurrence after surgical resection. Further, the aggressive ETS-negative 22RV1 cell line was identified as a SPINK1 outlier expression model. Reduction of SPINK1 in these cells could reduce invasion, suggesting a functional role for SPINK1 in ETS-negative prostate cancers.

These results identify SPINK1 as a biomarker specific to a subset of aggressive ETS-negative prostate cancers. Further studies are needed to determine the mechanism by which SPINK1 is overexpressed in ETS-negative cancers. "Our study also extends the utility of our original COPA approach by using a meta-COPA strategy to nominate candidate oncogenes in specific types of cancer," concludes Dr. Chinnaiyan.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Outing The Outliers: Strategy Matches Oncogene With Subtype Of Prostate Cancer." ScienceDaily. ScienceDaily, 11 June 2008. <www.sciencedaily.com/releases/2008/06/080609124616.htm>.
Cell Press. (2008, June 11). Outing The Outliers: Strategy Matches Oncogene With Subtype Of Prostate Cancer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/06/080609124616.htm
Cell Press. "Outing The Outliers: Strategy Matches Oncogene With Subtype Of Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2008/06/080609124616.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins