Featured Research

from universities, journals, and other organizations

Nanoparticles Aid Bone Growth

Date:
June 15, 2008
Source:
Rice University
Summary:
In the first study of its kind, bioengineers and bioscientists have shown they can grow denser bone tissue by sprinkling stick-like nanoparticles throughout the porous material used to pattern the bone.

In the first study of its kind, bioengineers and bioscientists at Rice University and Radboud University in Nijmegen, Netherlands, have shown they can grow denser bone tissue by sprinkling stick-like nanoparticles throughout the porous material used to pattern the bone.

Related Articles


The research is available online and slated to appear in the journal Bone. It's the latest breakthrough from the burgeoning field of tissue engineering. The new discipline combines the latest research in materials science and biomedical engineering to produce tissues that can be transplanted without risk of rejection.

To grow new bone, tissue engineers typically place bone cells on porous, biodegradable materials called scaffolds, which act as patterns. With the right chemical and physical cues, the cells can be coaxed into producing new bone. As the scaffold degrades, it is replaced by new bone.

"Ideally, a scaffold should be highly porous, nontoxic and biodegradable, yet strong enough to bear the structural load of the bone that will eventually replace it," said lead researcher Antonios Mikos, Rice's J.W. Cox Professor in Bioengineering, professor of chemical and biomolecular engineering and the director of Rice's Center for Excellence in Tissue Engineering. "Previous research has shown that carbon nanotubes give added strength to polymer scaffolds, but this is the first study to examine the performance of these materials in an animal model."

In the experiments, the researchers implanted two kinds of scaffolds into rabbits. One type was made of a biodegradable plastic called poly(propylene fumarate), or PPF, which has performed well in previous experiments. The second was made of 99.5 percent PPF and 0.5 percent single-walled carbon nanotubes. Nanotubes are about 80,000th the width of a hair. While they are normally about a thousand times longer than they are wide, the researchers used shorter segments that have fared well in prior cytocompatibility studies.

Half the samples were examined four weeks after implantation and half after 12 weeks. While there was no notable difference in performance at four weeks, the nanotube composites exhibited up to threefold greater bone ingrowth after 12 weeks than the PPF. Furthermore, the researchers found the 12-week composite scaffolds contained about two-thirds as much bone tissue as the nearby native bone tissue, while the PPF contained only about one-fifth as much.

Mikos said the nanocomposites performed better than anticipated. In fact, the results indicate that they may go beyond passive guides and take an active role in promoting bone growth.

"We don't yet know the exact mechanism of this enhanced bone formation, but we have intensive studies under way to find out," Mikos said. "It could be related to changes in surface chemistry, strength or other factors."

Co-authors on the paper include Rice former Ph.D. graduate student Xinfeng Shi, now a research scientist at Bausch & Lomb, and former postdoctoral fellow Balaji Sitharaman, now an assistant professor of biomedical engineering at State University of New York at Stony Brook; Lon Wilson, professor of chemistry at Rice; and John Jansen, Frank Walboomers, Hongbing Liao and Vincent Cuijpers, all of Radboud University Nijmegen Medical Center.

The research was funded by the National Institutes of Health, the National Science Foundation, the Robert A. Welch Foundation, and Rice's J. Evans-Attwell Postdoctoral Fellows Program.


Story Source:

The above story is based on materials provided by Rice University. Note: Materials may be edited for content and length.


Cite This Page:

Rice University. "Nanoparticles Aid Bone Growth." ScienceDaily. ScienceDaily, 15 June 2008. <www.sciencedaily.com/releases/2008/06/080613111847.htm>.
Rice University. (2008, June 15). Nanoparticles Aid Bone Growth. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2008/06/080613111847.htm
Rice University. "Nanoparticles Aid Bone Growth." ScienceDaily. www.sciencedaily.com/releases/2008/06/080613111847.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins