Featured Research

from universities, journals, and other organizations

New Role Of Inflammatory Protein In Polycycstic Kidney Disease Identified, Could Lead To Treatment

Date:
June 20, 2008
Source:
Stowers Institute for Medical Research
Summary:
Scientists have discovered that a protein previously shown to have a role in inflammation may also have a role in the formation of cysts in Autosomal Dominant Polycystic Kidney Disease -- one of the most common life-threatening genetic diseases -- and has shown that a drug inhibiting the protein can slow the disease in mice.

The Stowers Institute’s Rong Li Lab has discovered that a protein previously shown to have a role in inflammation may also have a role in the formation of cysts in Autosomal Dominant Polycystic Kidney Disease (ADPKD) — one of the most common life-threatening genetic diseases — and has shown that a drug inhibiting the protein can slow the disease in mice.

The discovery was published in the advance online publication of Nature Medicine June 12, 2008.

The team showed that a pro-inflammatory cytokine protein — tumor necrosis factor- α (TNF-α) — disrupts the localization of polycystin 2 (the product of a gene mutated in ADPKD) to the plasma membrane and primary cilia in kidney epithelial cells, thus promoting the formation of cysts.

“The interaction between TNF-α and polycystin in the development of cysts is complicated,” said Xiaogang Li, Ph.D., Senior Research Associate in the Rong Li Lab and first author on the paper. “We believe that this interaction could play a significant role in the transition from normal tubule development to the onset of Polycystic Kidney Disease (PKD) in individuals predisposed for the disease.”

Additionally, the team found that the drug etanercept, an inhibitor of TNF-α currently used to treat rheumatoid arthritis and a number of other conditions, prevents the formation of cysts in the kidneys of mice with ADPKD.

“This discovery is especially exciting because it not only provides insight about the origins of ADPKD, but it also points us toward a drug that we believe shows promise in preventing the development of cysts,” said Rong Li, Ph.D., Investigator and senior author on the publication. “Of course, additional research will be required to test these preliminary results in animal models, but the potential is interesting.”

Currently, no treatments are available to prevent or delay the onset of cysts in people living with PKD. Dialysis and kidney transplants are often required as the disease progresses.

Xiaogang Li received a grant from the PKD Foundation earlier this year. The award of $150,000 over two years supports his efforts to understand the origins of PKD.

Additional contributing authors from the Stowers Institute include Sheng Xia, Ph.D., Postdoctoral Research Associate; and Teri Johnson, Ph.D., Managing Director - Histology Facility. Also contributing from the University of Kansas Medical Center are James Calvet, Ph.D., Professor; Darren Wallace, Ph.D., Research Assistant Professor; and Brenda Magenheimer, Research Associate, who are supported by an NIH-funded P50 PKD Center grant.

In addition to her appointment at the Stowers Institute, Rong Li also is a Professor in the Department of Molecular & Integrative Physiology at the University of Kansas Medical Center.


Story Source:

The above story is based on materials provided by Stowers Institute for Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Stowers Institute for Medical Research. "New Role Of Inflammatory Protein In Polycycstic Kidney Disease Identified, Could Lead To Treatment." ScienceDaily. ScienceDaily, 20 June 2008. <www.sciencedaily.com/releases/2008/06/080616144852.htm>.
Stowers Institute for Medical Research. (2008, June 20). New Role Of Inflammatory Protein In Polycycstic Kidney Disease Identified, Could Lead To Treatment. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2008/06/080616144852.htm
Stowers Institute for Medical Research. "New Role Of Inflammatory Protein In Polycycstic Kidney Disease Identified, Could Lead To Treatment." ScienceDaily. www.sciencedaily.com/releases/2008/06/080616144852.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins