Featured Research

from universities, journals, and other organizations

Having Certain Type Of Herpes Virus Antibodies Linked With Form Of Diabetes In Sub-Saharan Africans

Date:
June 17, 2008
Source:
JAMA and Archives Journals
Summary:
Researchers have found an association between the presence of antibodies for the virus human herpesvirus 8 (HHV-8) and an atypical form of type 2 diabetes in persons from sub-Saharan Africa.

Researchers have found an association between the presence of antibodies for the virus human herpesvirus 8 (HHV-8) and an atypical form of type 2 diabetes in persons from sub-Saharan Africa, according to a preliminary study.

Related Articles


Since 1987, an atypical type of diabetes has emerged as one of the most frequent forms of diabetes in populations of African origin, ketosis-prone type 2 diabetes mellitus (DM-2). Ketosis is the condition of having ketone bodies (byproducts of fat metabolism) build up in body tissues and fluids. This type of diabetes is characterized by sudden onset, suggesting there may be triggering factors, according to background information in the article.

"In this study, we hypothesized that ketosis-prone DM-2 may be associated with a viral infection, which may also be the acute and reversible precipitating phenomenon. Indeed, viruses may induce both insulin resistance and insulin secretory defect," the authors write. "Because of the acute onset of ketosis-prone DM-2 and the high prevalence of ketosis-prone DM-2 in populations of African origin, we searched for a virus that is commonly found in this population." HHV-8 is endemic in sub-Saharan Africa with 30 percent to 60 percent of adults having markers of HHV-8 infection.

Eugθne Sobngwi, M.D., Ph.D., of Hτpital Saint-Louis, Paris, and colleagues tested the hypothesis that HHV-8 infection is associated with ketosis-prone DM-2. The study was conducted at Saint-Louis University Hospital in Paris from January 2004 to July 2005. All participants were black and of African origin: 187 were diabetic patients of whom 81 had ketosis-prone DM-2 and 106 had non-ketotic DM-2, and an additional 90 individuals were non-diabetic control participants who were matched for age and sex. The presence of HHV-8 in genomic DNA was investigated in 22 of the participants at clinical onset of diabetes.

HHV-8 antibodies were found in 71 patients (87.7 percent) with ketosis-prone DM-2 vs. 16 patients (15.1 percent) with non-ketotic DM-2, and 36 of the control participants (40.0 percent). HHV-8 in genomic DNA was present in 6 of 13 patients with ketosis-prone DM-2 tested at acute onset and in 0 of 9 patients with non-ketotic DM-2.

"Our preliminary study shows a strong link between ketosis-prone DM-2 phenotype and markers of HHV-8 infection. Patients with ketosis-prone DM-2 have a very high prevalence of HHV-8 infection, whereas patients with non-ketotic DM-2 have a much lower prevalence of HHV-8 infection when compared with the background population. Thus, the prevalence of HHV-8 seropositivity is almost 6-fold higher in patients with ketosis-prone DM-2 compared with non-ketotic DM-2 patients," the authors write.

"These results need to be replicated in other populations and longitudinal studies are required to understand the clinical significance of these findings."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eugene Sobngwi; Simeon Pierre Choukem; Felix Agbalika; Bertrand Blondeau; Lila-Sabrina Fetita; Celeste Lebbe; Doudou Thiam; Pierre Cattan; Jerome Larghero; Fabienne Foufelle; Pascal Ferre; Patrick Vexiau; Fabien Calvo; Jean-Francois Gautier. Ketosis-Prone Type 2 Diabetes Mellitus and Human Herpesvirus 8 Infection in Sub-Saharan Africans. JAMA, 2008;299(23):2770-2776 [link]

Cite This Page:

JAMA and Archives Journals. "Having Certain Type Of Herpes Virus Antibodies Linked With Form Of Diabetes In Sub-Saharan Africans." ScienceDaily. ScienceDaily, 17 June 2008. <www.sciencedaily.com/releases/2008/06/080617160829.htm>.
JAMA and Archives Journals. (2008, June 17). Having Certain Type Of Herpes Virus Antibodies Linked With Form Of Diabetes In Sub-Saharan Africans. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/06/080617160829.htm
JAMA and Archives Journals. "Having Certain Type Of Herpes Virus Antibodies Linked With Form Of Diabetes In Sub-Saharan Africans." ScienceDaily. www.sciencedaily.com/releases/2008/06/080617160829.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) — NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) — A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Microsoft Launches Fitness Band After Accidental Reveal

Microsoft Launches Fitness Band After Accidental Reveal

Newsy (Oct. 30, 2014) — Microsoft accidentally revealed its upcoming fitness band on Wednesday, so the company went ahead and announced it. Video provided by Newsy
Powered by NewsLook.com
Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

AFP (Oct. 30, 2014) — At the International Federation of Red Cross and Red Crescent Societies, around 30 doctors, nurses, lab technicians and water and sanitation workers are gathered for a crash-course in how to safely deal Ebola. Duration: 01:31 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins