Featured Research

from universities, journals, and other organizations

Blue Light Used To Harden Tooth Fillings Stunts Tumor Growth

Date:
June 28, 2008
Source:
Medical College of Georgia
Summary:
A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say.

Alpesh Patel, a rising MCG School of Dentistry junior, studies the effects of a blue curing light on tumors.
Credit: Phil Jones

A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say.

"The light sends wavelengths of blue-violet light to the composite, which triggers hardening," says Alpesh Patel, a rising MCG School of Dentistry junior. "The light waves produce free radicals that activate the catalyst and speed up polymerization of the composite resin. In oral cancer cells, though, those radicals cause damage that decreases cell growth and increases cell death."

Mr. Patel, who has been working with Dr. Jill Lewis, associate professor of oral biology, Dr. Regina Messer, associate professor of oral rehabilitation and oral biology, and Dr. John Wataha, adjunct professor of oral rehabilitation and oral biology, studied 10 tumor-bearing mice, five treated with the light and five untreated.

He exposed half the mice to the blue light for 90 seconds a day for 12 days. Then the tumors were extracted and each one was split into two sections. Half were used to create slides for tissue analysis, and half were frozen to prepare protein extracts.

Tissue analysis indicated an approximate 10 percent increase in cell suicide, or apoptosis, in the light-treated tumors. The frozen protein extracts revealed a nearly 80 percent decrease in cell growth in the light-treated tumors.

"The decrease in cell growth, combined with increased apoptosis, helps explain why the tumors didn't grow as much because you have cells that aren't dividing and you have cells that are committing suicide," Mr. Patel says.

Dr. Lewis predicts treating the tumors with blue light sooner will increase the rate of apoptosis, possibly preventing the tumor from ever becoming measurable and easing treatment.

"One desirable feature we've observed with the blue light is that non-cancerous cells appear unaffected at light doses that kill tumor cells," says Dr. Lewis. "We're thinking that some day, blue light therapy may serve as an adjunct to conventional cancer therapy. Patients may, therefore, receive lower doses of chemotherapy, which would decrease the adverse effects most cancer patients experience from standard chemotherapy regimens."

Mr. Patel presented his findings at the 2008 American Association for Dental Research Student Research Group DENTSPLY/Caulk competition, winning third place in the basic science category. He and rising junior MCG School of Dentistry student Beth Rainwater were two of only seven students nationwide to be selected for the competition.


Story Source:

The above story is based on materials provided by Medical College of Georgia. Note: Materials may be edited for content and length.


Cite This Page:

Medical College of Georgia. "Blue Light Used To Harden Tooth Fillings Stunts Tumor Growth." ScienceDaily. ScienceDaily, 28 June 2008. <www.sciencedaily.com/releases/2008/06/080624110831.htm>.
Medical College of Georgia. (2008, June 28). Blue Light Used To Harden Tooth Fillings Stunts Tumor Growth. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2008/06/080624110831.htm
Medical College of Georgia. "Blue Light Used To Harden Tooth Fillings Stunts Tumor Growth." ScienceDaily. www.sciencedaily.com/releases/2008/06/080624110831.htm (accessed October 2, 2014).

Share This



More Matter & Energy News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Japan Looks To Faster Future As Bullet Train Turns 50

Japan Looks To Faster Future As Bullet Train Turns 50

Newsy (Oct. 1, 2014) Japan's bullet train turns 50 Wednesday. Here's a look at how it's changed over half a century — and the changes it's inspired globally. Video provided by Newsy
Powered by NewsLook.com
US Police Put Body Cameras to the Test

US Police Put Body Cameras to the Test

AFP (Oct. 1, 2014) Police body cameras are gradually being rolled out across the US, with interest surging after the fatal police shooting in August of an unarmed black teenager. Duration: 02:18 Video provided by AFP
Powered by NewsLook.com
Raw: Japan Celebrates 'bullet Train' Anniversary

Raw: Japan Celebrates 'bullet Train' Anniversary

AP (Oct. 1, 2014) A ceremony marking 50 years since Japan launched its Shinkansen bullet train was held on Wednesday in Tokyo. The latest model can travel from Tokyo to Osaka, a distance of 319 miles, in two hours and 25 minutes. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins