Featured Research

from universities, journals, and other organizations

Cells Have An Appetite For Micro-doughnuts

Date:
June 24, 2008
Source:
Royal Society of Chemistry
Summary:
Just like humans, liver cells can't resist eating just one or two small doughnuts, say chemists in the Royal Society of Chemistry journal Chemical Communications. Exploiting liver cells' appetite for polystyrene ring "doughnuts", just a few microns across, might give scientists a new way to deliver drugs selectively, potentially eliminating nasty side effects of life-saving treatments such as chemotherapy.

SEM image of the micro-doughnuts.
Credit: Image courtesy of Royal Society of Chemistry

Just like humans, liver cells can’t resist eating just one or two small doughnuts, say chemists from Scotland in the Royal Society of Chemistry journal Chemical Communications.

Exploiting liver cells’ appetite for polystyrene ring “doughnuts”, just a few microns across, might give scientists a new way to deliver drugs selectively, potentially eliminating nasty side effects of life-saving treatments such as chemotherapy.

Mark Bradley and colleagues at the University of Edinburgh, UK, serendipitously made the polymer doughnuts while studying potential drug-carrying microparticles.

While synthesising micro-spheres, the team added a small amount of dioxane to their usual ethanol solvent. To their surprise, the resulting microparticles were regular in size and shape, with a hole through the middle like a doughnut.

“Their unique and highly uniform structure was immediately interesting to us and we considered the possible applications they may have – one of which was as carrier particles for cellular delivery,” said Bradley.

When they tested the uptake of the doughnuts into different types of cells, the team found they had an overwhelming preference for liver cells.

The high cell specificity these doughnuts showed led the team to conduct extensive in vivo testing in rats. The doughnuts were injected into the tail and within four hours they were detected solely in the liver region (yellow in image), with no adverse effects observed in the animal after the experiment.

Bradley believes there are other uses for the micro-doughnuts besides drug delivery, such as filtration or purification devices, but the team will be keen to develop their ability to selectively deliver drugs into cells.


Story Source:

The above story is based on materials provided by Royal Society of Chemistry. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lois Alexander et al. Dunking doughnuts into cells—selective cellular translocation and in vivo analysis of polymeric micro-doughnuts. Chemical Communications, 2008; DOI: 10.1039/b805323e

Cite This Page:

Royal Society of Chemistry. "Cells Have An Appetite For Micro-doughnuts." ScienceDaily. ScienceDaily, 24 June 2008. <www.sciencedaily.com/releases/2008/06/080624120237.htm>.
Royal Society of Chemistry. (2008, June 24). Cells Have An Appetite For Micro-doughnuts. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/06/080624120237.htm
Royal Society of Chemistry. "Cells Have An Appetite For Micro-doughnuts." ScienceDaily. www.sciencedaily.com/releases/2008/06/080624120237.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins