Featured Research

from universities, journals, and other organizations

Mechanism Explains Calcium Abnormalities In Alzheimer's Brain

Date:
June 27, 2008
Source:
Cell Press
Summary:
A new study uncovers a mechanism that directly links mutations that cause early onset Alzheimer's disease with aberrant calcium signaling. The research, published by Cell Press in the June 26 issue of the journal Neuron, provides exciting molecular insights into the pathology of AD and may lead to new treatment strategies.

A new study uncovers a mechanism that directly links mutations that cause early onset Alzheimer's disease (AD) with aberrant calcium signaling. The research, published by Cell Press in the June 26th issue of the journal Neuron, provides exciting molecular insights into the pathology of AD and may lead to new treatment strategies.

AD is a devastating neurodegenerative disease that affects early 18 million people in the world. Most cases of AD occur spontaneously after the age of 60 but about 10% of cases are inherited and can develop decades earlier. Early onset familial AD (FAD) is caused by mutated amyloid precursor protein, which can lead to aggregation of sticky clumps of amyloid beta protein in the brain, and mutated presenilins (PS), enzymes which have been implicated in amyloid processing.

Recent research has also linked mutant PS expression with exaggerated intracellular calcium release in several model systems, including cells from FAD patients. "Accumulating evidence suggests that sustained disruption of intracellular calcium signaling may play an early role in AD pathogenesis," says study author Dr. J. Kevin Foskett from the University of Pennsylvania. Calcium plays a central role in many aspects of brain physiology including growth, plasticity and learning and memory as well as cell death and degeneration.

Dr. Foskett and colleagues found that biochemical interactions of FAD mutant PS with an intracellular calcium release channel, called inositol trisphosphate receptor (InsP3R), profoundly increased channel activity in a manner that could account for exaggerated calcium responses in cells exposed to normal stimulation and caused low level calcium signaling in unstimulated cells. The researchers went on to show that this enhancement of channel activity was directly involved in mutant PS-mediated amyloid beta generation, a hallmark of AD.

"We have discovered a mechanism that can account for altered calcium signaling in AD cells that involves a biochemical and functional interaction of FAD mutant PS with the InsP3R calcium release channel. These observations provide unique molecular insights into the calcium dysregulation hypothesis of AD pathogenesis and they suggest novel targets for therapeutic intervention," concludes Dr. Foskett.

In a related finding, published in the June 27th issue of the journal Cell, abnormal calcium signaling was also linked to the more common spontaneously occurring form of AD. In this study, Dr. Fabien Campagne from Weill Medical College, Dr. Philippe Marambaud from Albert Einstein College of Medicine and their colleagues discovered a mutation associated with late onset, sporadic AD that disrupted a previously uncharacterized brain calcium channel and led to subsequent accumulation of amyloid beta protein. Therefore, dysregulation of intracellular calcium levels appears to play a role in both sporadic and hereditary AD.

The researchers include King-Ho Cheung, University of Pennsylvania, Philadelphia, PA; Diana Shineman, University of Pennsylvania, Philadelphia, PA; Marioly Muller, University of Pennsylvania, Philadelphia, PA; Cesar Cardenas, University of Pennsylvania, Philadelphia, PA; Lijuan Mei, University of Pennsylvania, Philadelphia, PA; Jun Yang, University of Pennsylvania, Philadelphia, PA; Taisuke Tomita, University of Tokyo, Tokyo, Japan; Takeshi Iwatsubo, University of Tokyo, Tokyo, Japan; Virginia M.-Y. Lee, University of Pennsylvania, Philadelphia, PA; and J. Kevin Foskett, University of Pennsylvania, Philadelphia, PA.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal References:

  1. Cheung et al. Mechanism of Ca2 Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating. Neuron, Vol 58, 871-883, 26 June 2008 [link]
  2. Dreses-Werringloer et al. A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer’s Disease Risk. Cell, 133, 1149-1161, June 27, 2008 DOI: 10.1016/j.cell.2008.05.048

Cite This Page:

Cell Press. "Mechanism Explains Calcium Abnormalities In Alzheimer's Brain." ScienceDaily. ScienceDaily, 27 June 2008. <www.sciencedaily.com/releases/2008/06/080625122915.htm>.
Cell Press. (2008, June 27). Mechanism Explains Calcium Abnormalities In Alzheimer's Brain. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2008/06/080625122915.htm
Cell Press. "Mechanism Explains Calcium Abnormalities In Alzheimer's Brain." ScienceDaily. www.sciencedaily.com/releases/2008/06/080625122915.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com
Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins