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In Spain, 6 Of Every 100 Patients Die In Hospital Due To Adverse Drug Reaction, Study Suggests

Date:
July 9, 2008
Source:
Universidad de Granada
Summary:
A new study in Spain determined that six of every 100 patients who die in hospital do so as a consequence of an adverse drug reaction or, in other words, a fatal reaction to medicines. A adverse drug reaction to medicines (ADR) has been defined as any harmful and unwanted effect of a drug, at doses used for prophylaxis, diagnose or treatment.
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Six of every 100 patients who die in hospital do so as a consequence of an adverse drug reaction or, in other words, a fatal reaction to medicines. A adverse drug reaction to medicines (ADR) has been defined as any harmful and unwanted effect of a drug, at doses used for prophylaxis, diagnose or treatment.

Their repercussion is usually minimal, but sometimes, they can be serious and they can even endanger the patient’s life.

The research was carried out at the Department of Medicine of the University of Granada, in collaboration with the Clinical Hospital San Cecilio of Granada, by Alfredo José Pardo Cabello and directed by Professors Emilio Puche Cañas (Department of Pharmacology) and Francisco Javier Gómez Jiménez (Department of Medicine).

In order to carry out this work, they analysed the clinical case history of 289 patients older than 18 who died in hospital in 2004, revising their history, the drugs they were administered, as well as data about the treatment and the death certificate. Their analysis concluded that the most frequent ADR are the digestive haemorrhages followed by intra-cranial haemorrhages and cardiac arrhythmias.

Most frequent drugs

The work carried out at the UGR has revealed that the drugs which provoked an ADR usually were AINE (medicines with a strong anti-inflammatory, analgesic and antipyretic effect) as well as platelet anti-aggregants, such as acetylsalicylic acid, two types of drugs frequently used in the daily medical practice.

Pardo Cabello has also shown the importance of avoiding the mixing of gastro-damaging drugs such as NSAIDs, anti-aggregants and corticoids, as 53% of the deaths caused by ADR analyzed in this study had received a mixing of such medicines.

The author of this work has highlighted that, in the light of the obtained results, it is necessary to create a better awareness among the sanitary staff about adverse drug reactions and to be on the alert in the face of the slightest symptom. These results, obtained in Spain, are in line with similar studies carried out in USA and Finland.


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The above story is based on materials provided by Universidad de Granada. Note: Materials may be edited for content and length.


Cite This Page:

Universidad de Granada. "In Spain, 6 Of Every 100 Patients Die In Hospital Due To Adverse Drug Reaction, Study Suggests." ScienceDaily. ScienceDaily, 9 July 2008. <www.sciencedaily.com/releases/2008/07/080707112653.htm>.
Universidad de Granada. (2008, July 9). In Spain, 6 Of Every 100 Patients Die In Hospital Due To Adverse Drug Reaction, Study Suggests. ScienceDaily. Retrieved May 28, 2015 from www.sciencedaily.com/releases/2008/07/080707112653.htm
Universidad de Granada. "In Spain, 6 Of Every 100 Patients Die In Hospital Due To Adverse Drug Reaction, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/07/080707112653.htm (accessed May 28, 2015).

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