Featured Research

from universities, journals, and other organizations

Protein Marker For Schizophrenia Risk

Date:
July 10, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
A protein found in immune cells may be a reliable marker for schizophrenia risk, report researchers in a new proteomics study. Schizophrenia is a severe and complex psychiatric illness that affects about 1% of the population.

A protein found in immune cells may be a reliable marker for schizophrenia risk, report researchers in a new proteomics study.

Related Articles


Schizophrenia is a severe and complex psychiatric illness that affects about 1% of the population. Diagnosis currently relies on subjective clinical interviews and the assessment of ambiguous symptoms, which frequently leads to delayed diagnosis and treatment. As such, biomarkers that would indicate schizophrenia risk or onset would be extremely useful.

Sabine Bahn and colleagues sought to find such a "protein fingerprint" in the blood (due to its accessibility). They compared protein profiles of schizophrenia patients and controls using mass spectrometry and identified two peaks highlighting a significant change. These were identified as alpha defensins, proteins responsible for killing microbes and viruses in the innate immune response.

Bahn and colleagues confirmed their findings by examining alpha defensin levels in the blood of 21 twin pairs discordant for schizophrenia (where one sibling manifests the disease while the other does not). In these twin sets, both siblings had significantly elevated alpha defensins as compared with a group of control twins. Changes were also found in patients who were investigated soon after diagnosis, which means that higher levels of alpha defensins were not caused by medication or progression of the disease.

Because both discordant twins had elevated alpha defensins, these proteins do not indicate disease onset, but the researchers suggest they could be a useful and simple marker for evaluating schizophrenia risk. Although they believe that more markers will be needed in order to develop a sensitive and specific schizophrenia blood test.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rachel M. Craddock, Jeffrey Huang, Edmund Jackson, Nathan Harris, E. Fuller Torrey, Marlis Herberth and Sabine Bahn. Increased alpha-defensins as a blood marker for schizophrenia susceptibility. Molecular and Cellular Proteomics, July, 2008 [link]

Cite This Page:

American Society for Biochemistry and Molecular Biology. "Protein Marker For Schizophrenia Risk." ScienceDaily. ScienceDaily, 10 July 2008. <www.sciencedaily.com/releases/2008/07/080708155559.htm>.
American Society for Biochemistry and Molecular Biology. (2008, July 10). Protein Marker For Schizophrenia Risk. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/07/080708155559.htm
American Society for Biochemistry and Molecular Biology. "Protein Marker For Schizophrenia Risk." ScienceDaily. www.sciencedaily.com/releases/2008/07/080708155559.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins