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Model For Automated, Wearable Artificial Kidney Designed

Date:
July 12, 2008
Source:
University of California - Los Angeles
Summary:
Two researchers have developed a design for an automated, wearable artificial kidney, or AWAK, that avoids the complications patients often suffer with traditional dialysis. The peritoneal-based artificial kidney is "bloodless" and reduces or even eliminates protein loss and other dialysis-related problems.

AWAK Slide 1 waterless dialysis diagram.
Credit: Image courtesy of University of California - Los Angeles

Two researchers from UCLA and the Veterans Affairs Greater Los Angeles Healthcare System have developed a design for an automated, wearable artificial kidney, or AWAK, that avoids the complications patients often suffer with traditional dialysis.

The peritoneal-based artificial kidney is "bloodless" and reduces or even eliminates protein loss and other dialysis-related problems.

UCLA--VA has also signed an exclusive licensing agreement with the Singapore-based company AWAK Technologies Pte. Ltd. to develop a commercial wearable kidney based on the design by Martin Roberts, an assistant professor of clinical medicine at the David Geffen School of Medicine at UCLA and a dialysis consultant with the VA Healthcare System, and David B.N. Lee, a professor of medicine at the Geffen School and a consultant nephrologist at the VA.

Around 1980, an artificial kidney machine was built that incorporated many of the principles on which the new technology relies, according to Roberts. But that machine, while portable, was not wearable. The new technology would allow patients to go about their regular business while undergoing dialysis.

"What's really new about it is the patient's freedom," Roberts said. "To me, as the inventor, the most important thing for the patients is their freedom. The next important thing is that because it's working all the time instead of intermittently, you can do a much better job of treating the patient. So we expect the patient to feel better and live longer."

Kidneys remove metabolic wastes from the body and regulate fluid volume and distribution on a continuous, around-the-clock basis. With traditional hemodialysis, patients are hooked up to a machine for four hours, three times a week. Their blood is filtered through the machine to remove toxins and is then pumped back into the body. What hemodialysis can't do, however, is provide cleansing and fluid balance on a continuous basis; therefore, toxin levels and fluid volume tend to fluctuate, causing "shocks" to the patient's system. The same is true of standard peritoneal-based dialysis.

In addition, hemodialysis uses anticoagulants to prevent the blood circulating outside the body from clotting. But this, too, can cause complications. Work on other wearable kidneys has been based on this hemodialysis or hemofiltration model.

The AWAK, on the other hand, would function continuously, as natural kidneys do, eliminating patient "shocks." And because it does not involve blood circulation outside the body, it is "bloodless." It also regenerates and reuses fluid and protein components in the spent dialysate -- the fluid that has abstracted toxins from the patient's blood and which is discarded in current practice -- making it waterless and minimizing or eliminating protein loss.

"Dialysis-on-the-go, made possible by AWAK's 'wearability' and automation, frees end-stage renal failure patients from the servitude that is demanded by the current dialytic regimentations," Roberts and Lee write in the journal article.

Working out of the VA Greater Los Angeles Healthcare System, Roberts and Lee funded their research that led to the invention.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Journal Reference:

  1. Review article David B. N. Lee and Martin Roberts. A peritoneal-based automated wearable artificial kidney. Clinical and Experimental Nephrology, Volume 12, Number 3 / June, 2008 DOI: 10.1007/s10157-008-0050-9

Cite This Page:

University of California - Los Angeles. "Model For Automated, Wearable Artificial Kidney Designed." ScienceDaily. ScienceDaily, 12 July 2008. <www.sciencedaily.com/releases/2008/07/080710153015.htm>.
University of California - Los Angeles. (2008, July 12). Model For Automated, Wearable Artificial Kidney Designed. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2008/07/080710153015.htm
University of California - Los Angeles. "Model For Automated, Wearable Artificial Kidney Designed." ScienceDaily. www.sciencedaily.com/releases/2008/07/080710153015.htm (accessed July 30, 2014).

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