Featured Research

from universities, journals, and other organizations

Metabolic Disease: Understanding How The Brain Can Influence The Effects Of Insulin

Date:
July 14, 2008
Source:
Journal of Clinical Investigation
Summary:
One of the characteristics of type 2 diabetes is insulin resistance, which refers to the inability of cells in the body to respond appropriately to the hormone insulin. Among the cells in the body that normally respond to insulin are nerves in a region of the brain known as the hypothalamus. Now, new research provides insight into a molecular pathway in the hypothalamus that contributes to the development of insulin resistance.

One of the characteristics of type 2 diabetes is insulin resistance, which refers to the inability of cells in the body to respond appropriately to the hormone insulin. Among the cells in the body that normally respond to insulin are nerves in a region of the brain known as the hypothalamus.

New data, generated in rats, by Hiraku Ono and colleagues, at Albert Einstein College of Medicine, New York, has provided insight into a molecular pathway in the hypothalamus that contributes to the development of insulin resistance.

Insulin plays a key role in controlling the amount of glucose in the body through its ability to make cells, such as liver and fat cells, take up glucose from the blood and store it for future use. Insulin also prevents liver cells from releasing stored glucose, partly through its effects in the hypothalamus. In the study, if rats were fed a high-fat diet for a short period of time the ability of insulin to prevent liver cells releasing stored glucose was reduced. This was associated with both a decrease in insulin-induced signaling and an increase in activation of a protein known as SK6 in the hypothalamus.

The importance of SK6 activation in the hypothalamus in suppressing the ability of insulin to prevent glucose release from liver cells was confirmed by two sets of experiments. First, it was shown that enforced SK6 activation in the hypothalamus had the same effects as feeding rats a high-fat diet; second, blocking the effects of SK6 activation restored the ability of insulin to prevent glucose release from liver cells, even when rats were fed a high-fat diet. These data lead the authors to speculate that the earliest stages of diet-induced insulin resistance might be prevented by inhibition of S6K in the hypothalamus.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. Journal of Clinical Investigation, July 10, 2008

Cite This Page:

Journal of Clinical Investigation. "Metabolic Disease: Understanding How The Brain Can Influence The Effects Of Insulin." ScienceDaily. ScienceDaily, 14 July 2008. <www.sciencedaily.com/releases/2008/07/080710180013.htm>.
Journal of Clinical Investigation. (2008, July 14). Metabolic Disease: Understanding How The Brain Can Influence The Effects Of Insulin. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2008/07/080710180013.htm
Journal of Clinical Investigation. "Metabolic Disease: Understanding How The Brain Can Influence The Effects Of Insulin." ScienceDaily. www.sciencedaily.com/releases/2008/07/080710180013.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins