Featured Research

from universities, journals, and other organizations

A Potential Metastatic Disease Target?

Date:
July 20, 2008
Source:
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Summary:
Researchers have identified a type of cancer stem cell that might initiate metastatic cancer, which spreads beyond the original, primary tumor site and to other locations within the body. For the first time, scientists have revealed that the molecular profiles of these cancer stem cells are much different than those located in primary tumors.

Researchers from Weill Cornell Medical College have identified a type of cancer stem cell that might initiate metastatic cancer, which spreads beyond the original, primary tumor site and to other locations within the body.

Related Articles


For the first time, scientists have revealed that the molecular profiles of these cancer stem cells are much different than those located in primary tumors.

The study's senior author Dr. Shahin Rafii — the Arthur B. Belfer Professor in Genetic Medicine and director of the Ansary Center for Stem Cell Therapeutics at Weill Cornell and a noted investigator at the Howard Hughes Medical Institute — believes that these findings pave the way for research into a new subset of metastatic cancer stem cells, previously unidentified.

It has long been thought that a protein called CD133 is produced by all cancer stem cells, which are responsible for the creation and maintenance of tumors. But now, the research team found that certain metastatic stem cells (CD133-negative) do not produce this well-known protein.

The scientists studied colon cancer cells within a mouse model to make their observations. Moving forward, the findings may spur research to identify new biomarkers, specific to metastatic cancer stem cells, which may lead to the development of drugs that target metastatic cancer.

The study's results were released as a special "highlighted" article in a recent issue of the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. Note: Materials may be edited for content and length.


Cite This Page:

New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. "A Potential Metastatic Disease Target?." ScienceDaily. ScienceDaily, 20 July 2008. <www.sciencedaily.com/releases/2008/07/080718080323.htm>.
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. (2008, July 20). A Potential Metastatic Disease Target?. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/07/080718080323.htm
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College. "A Potential Metastatic Disease Target?." ScienceDaily. www.sciencedaily.com/releases/2008/07/080718080323.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins