Featured Research

from universities, journals, and other organizations

Averting Postsurgical Infections In Kids: Give Antibiotics Within Hour Before First Incision, Study Suggests

Date:
July 22, 2008
Source:
Johns Hopkins Medical Institutions
Summary:
Giving children preventive antibiotics within one hour before they undergo spinal surgery greatly reduces the risk for serious infections after the surgery, suggests a study to be published in the Pediatric Infectious Disease Journal.

Giving children preventive antibiotics within one hour before they undergo spinal surgery greatly reduces the risk for serious infections after the surgery, suggests a Johns Hopkins study.

Children who received antibiotics outside of the golden one-hour window were three and half times more likely to develop serious infections at the surgery site, researchers report, pointing out that something as simple as ensuring that a child gets timely prophylaxis can prevent serious complications and reduce the length of hospital stay.

"When it comes to preventing infections, when a child gets antibiotics appears to be one of the most critical yet most easily modifiable risk factors, and may matter just as much as the type and dosage of the medication ,"says lead researcher Aaron Milstone, M.D., infectious disease specialist at the Johns Hopkins Children's Center. "The moral of this is that an ounce of timely prevention is indeed worth a pound of treatment."

Nearly 780,000 postsurgical infections occur in the United States each year, according to estimates from the Institute for Healthcare Improvement. An infection after surgery nearly doubles a patient's risk of death, doubles a patient's hospital stay and adds up to $50,000 to treatment costs per patient, researchers say.

While preoperative antibiotic prophylaxis is standard in adults, there are no standard guidelines on how to administer antibiotics in children undergoing surgery.

Reviewing nearly 1,000 spinal fusion surgeries performed in children over a six-year period at Hopkins, investigators found 36 deep surgical site infections. More serious than superficial skin infections, these can cause serious complications and require aggressive treatment including additional surgeries and long-term antibiotics. Of the 36 cases, 28 percent received medication outside the one-hour window, either more than an hour before incision or after the surgery began. Other factors affecting infection risk included underlying medical conditions and previous spinal surgeries, researchers found.

Even though spinal fusion surgeries are complex procedures and thus carry higher risk for deep-site infections, the findings are likely relevant to many types of surgical procedures, the researchers say, because timing is always critical when administering antibiotics, either as treatment or prevention.

The research was funded by grants from the Centers for Disease Control and the Pediatric Infectious Diseases Society.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Journal Reference:

  1. Aaron M. Milstone, MD; Lisa L. Maragakis, MD, MPH; Timothy Townsend, MD; Kathleen Speck, MPH; Paul Sponseller, MD; Xiaoyan Song, PhD; Trish M. Perl, MD, MSc. Timing of Preoperative Antibiotic Prophylaxis: A Modifiable Risk Factor for Deep Surgical Site Infections After Pediatric Spinal Fusion. Pediatric Infectious Disease Journal, August 2008 DOI: 10.1097/INF.0b013e31816fca72

Cite This Page:

Johns Hopkins Medical Institutions. "Averting Postsurgical Infections In Kids: Give Antibiotics Within Hour Before First Incision, Study Suggests." ScienceDaily. ScienceDaily, 22 July 2008. <www.sciencedaily.com/releases/2008/07/080718125853.htm>.
Johns Hopkins Medical Institutions. (2008, July 22). Averting Postsurgical Infections In Kids: Give Antibiotics Within Hour Before First Incision, Study Suggests. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2008/07/080718125853.htm
Johns Hopkins Medical Institutions. "Averting Postsurgical Infections In Kids: Give Antibiotics Within Hour Before First Incision, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2008/07/080718125853.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins