Featured Research

from universities, journals, and other organizations

Thyrotropin Levels Associated With Alzheimer's Disease Risk In Women

Date:
July 30, 2008
Source:
JAMA and Archives Journals
Summary:
Women with low or high levels of the hormone thyrotropin, which affects thyroid gland function and thyroid hormone levels, appear to have a higher risk of developing Alzheimer's disease, according to a report in the July 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Women with low or high levels of the hormone thyrotropin, which affects thyroid gland function and thyroid hormone levels, appear to have a higher risk of developing Alzheimer's disease, according to a report in the July 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

A clinically detectable over- or under-active thyroid has long been recognized as a potentially reversible cause of cognitive (thinking, learning and memory) impairment, according to background information in the article. Previous studies have examined whether levels of thyrotropin, a hormone that is secreted by the pituitary gland and helps regulate thyroid gland function, is associated with cognitive performance in individuals with normal thyroid function. However, results have been inconsistent.

Zaldy S. Tan, M.D., M.P.H., of Hebrew SeniorLife, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, and colleagues measured thyrotropin levels in 1,864 individuals (average age 71) without cognitive problems between 1977 and 1979. Participants—part of the community-based Framingham Study—were assessed for dementia at that time and again every two years.

Over an average of 12.7 years of follow-up, 209 participants developed Alzheimer's disease. After adjusting for other related factors, the researchers found that women with the lowest (less than 1 milli-international unit per liter) and highest (more than 2.1 milli-international units per liter) levels of thyrotropin had more than double the risk of developing Alzheimer's disease. However, no relationship was observed between thyrotropin levels and Alzheimer's disease risk in men.

"Whether altered thyrotropin levels occur before or after the onset of Alzheimer's disease, the neuropathologic mechanism is unclear," the authors write. Changes in the brain caused by Alzheimer's disease may cause a reduction in the amount of thyrotropin released or changes in the body's responsiveness to the hormone. Alternatively, low or high thyrotropin levels could damage neurons or blood vessels, leading to cognitive difficulties.

"In conclusion, low and high thyrotropin levels were associated with an increased risk of incident Alzheimer's disease in women but not in men," the authors conclude. "These findings should be considered hypothesis–generating and should be validated in other populations before clinical conclusions are drawn."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zaldy S. Tan; Alexa Beiser; Ramachandran S. Vasan; Rhoda Au; Sanford Auerbach; Douglas P. Kiel; Philip A. Wolf; Sudha Seshadri. Thyroid Function and the Risk of Alzheimer Disease. Arch Intern Med, 2008;168[14]:1514-1520

Cite This Page:

JAMA and Archives Journals. "Thyrotropin Levels Associated With Alzheimer's Disease Risk In Women." ScienceDaily. ScienceDaily, 30 July 2008. <www.sciencedaily.com/releases/2008/07/080728192807.htm>.
JAMA and Archives Journals. (2008, July 30). Thyrotropin Levels Associated With Alzheimer's Disease Risk In Women. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2008/07/080728192807.htm
JAMA and Archives Journals. "Thyrotropin Levels Associated With Alzheimer's Disease Risk In Women." ScienceDaily. www.sciencedaily.com/releases/2008/07/080728192807.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins