Featured Research

from universities, journals, and other organizations

How Bacteria Attach To Human Tissues During Infection Process: New Clues

Date:
August 7, 2008
Source:
University of York
Summary:
Scientists have helped to reveal more about the way bacteria can attach to human tissues. The researchers studied the way a protein found on the surface of the bacteria Staphylococcus aureus binds to a human protein called fibronectin. Their discovery is an important step in understanding how bacteria attach to the surface of blood vessels during infection.

Scientists at the University of York have helped to reveal more about the way bacteria can attach to human tissues. The study could help in the development of new treatments for serious heart conditions such as infective endocarditis.

The researchers studied the way a protein found on the surface of the bacteria Staphylococcus aureus binds to a human protein called fibronectin. Their discovery is an important step in understanding how bacteria attach to the surface of blood vessels during infection.

The high-resolution structures of parts of the bacterial protein in complex with multiple fibronectin domains reveals the efficiency with which the bacterial molecule can bind several copies of the human protein, a feature thought to play a role in infection.

Dr Jennifer Potts of the Departments of Biology and Chemistry at York, who led the research said: "Interactions of S. aureus with fibronectin were first reported more than 30 years ago, and yet we still don’t understand precisely how and why the bacteria target this human protein.

"Our studies provide a significant step toward solving that issue and could help the future development of new treatments for rare but serious conditions such as infective endocarditis, an infection of the lining or valves of the heart."

The work, which was funded by the British Heart Foundation, the Biotechnology and Biological Sciences Research Council, and the Wellcome Trust, was undertaken by Dr Richard Bingham and Dr Nicola Meenan (Biology, York) in collaboration with other scientists at the Universities of York, Oxford, St Andrews, UNAM and the TAMU Health Science Centre, Institute of Biosciences and Technology, Houston.

The research used the York Structural Biology Laboratory (YSBL) at the University of York and facilities at the European Synchrotron Radiation Facility (ESRF) in Grenoble.


Story Source:

The above story is based on materials provided by University of York. Note: Materials may be edited for content and length.


Journal Reference:

  1. Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains. Proceedings of the National Academy of Sciences, (in press)

Cite This Page:

University of York. "How Bacteria Attach To Human Tissues During Infection Process: New Clues." ScienceDaily. ScienceDaily, 7 August 2008. <www.sciencedaily.com/releases/2008/08/080806113143.htm>.
University of York. (2008, August 7). How Bacteria Attach To Human Tissues During Infection Process: New Clues. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2008/08/080806113143.htm
University of York. "How Bacteria Attach To Human Tissues During Infection Process: New Clues." ScienceDaily. www.sciencedaily.com/releases/2008/08/080806113143.htm (accessed April 17, 2014).

Share This



More Plants & Animals News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Raw: Three Rare White Tiger Cubs Debut at Zoo

Raw: Three Rare White Tiger Cubs Debut at Zoo

AP (Apr. 16, 2014) The Buenos Aires Zoo debuted a trio of rare white Bengal tiger cubs on Wednesday. (April 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins